Cerussi Albert E, Warren Robert, Hill Brian, Roblyer Darren, Leproux Anaїs, Durkin Amanda F, O'Sullivan Thomas D, Keene Sam, Haghany Hosain, Quang Timothy, Mantulin William M, Tromberg Bruce J
Beckman Laser Institute, University of California Irvine, Irvine, California 92617, USA.
Biomed Opt Express. 2012 May 1;3(5):966-71. doi: 10.1364/BOE.3.000966. Epub 2012 Apr 16.
Tissue simulating phantoms are an important part of instrumentation validation, standardization/training and clinical translation. Properly used, phantoms form the backbone of sound quality control procedures. We describe the development and testing of a series of optically turbid phantoms used in a multi-center American College of Radiology Imaging Network (ACRIN) clinical trial of Diffuse Optical Spectroscopic Imaging (DOSI). The ACRIN trial is designed to measure the response of breast tumors to neoadjuvant chemotherapy. Phantom measurements are used to determine absolute instrument response functions during each measurement session and assess both long and short-term operator and instrument reliability.
组织模拟体模是仪器验证、标准化/培训以及临床转化的重要组成部分。如果使用得当，体模构成了完善的质量控制程序的基础。我们描述了一系列光学浑浊体模的开发和测试，这些体模用于美国放射学会成像网络（ACRIN）的一项多中心弥漫光学光谱成像（DOSI）临床试验。ACRIN试验旨在测量乳腺肿瘤对新辅助化疗的反应。体模测量用于确定每次测量期间的绝对仪器响应函数，并评估长期和短期的操作人员及仪器可靠性。
