利用组合漫射光学光谱成像和漫射相关光谱技术在人体中绘制乳腺癌血流指数、组成和代谢图谱。
Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy.
机构信息
University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
University of California, Chao Family Comprehensive Cancer Center, Orange, California, United States.
出版信息
J Biomed Opt. 2017 Apr 1;22(4):45003. doi: 10.1117/1.JBO.22.4.045003.
Abstract
Diffuse optical spectroscopic imaging (DOSI) and diffuse correlation spectroscopy (DCS) are model-based near-infrared (NIR) methods that measure tissue optical properties (broadband absorption, ? a , and reduced scattering, ? s ? ) and blood flow (blood flow index, BFI), respectively. DOSI-derived ? a values are used to determine composition by calculating the tissue concentration of oxy- and deoxyhemoglobin ( HbO 2 , HbR), water, and lipid. We developed and evaluated a combined, coregistered DOSI/DCS handheld probe for mapping and imaging these parameters. We show that uncertainties of 0.3 ?? mm ? 1 (37%) in ? s ? and 0.003 ?? mm ? 1 (33%) in ? a lead to ? 53 % and 9% errors in BFI, respectively. DOSI/DCS imaging of a solid tissue-simulating flow phantom and
摘要
漫射光学光谱成像（DOSI）和漫射相关光谱（DCS）是基于模型的近红外（NIR）方法，分别测量组织光学特性（宽带吸收，？a和散射减少，？s？）和血流（血流指数，BFI）。DOSI 衍生的？a 值用于通过计算氧合和脱氧血红蛋白（HbO2，HbR）、水和脂质的组织浓度来确定组成。我们开发并评估了一种组合的、配准的 DOSI/DCS 手持式探头，用于绘制和成像这些参数。我们表明，？s？的不确定度为 0.3?? mm? 1（37%），？a？的不确定度为 0.003?? mm? 1（33%），分别导致 BFI 的误差为 53%和 9%。固态组织模拟流动体模的 DOSI/DCS 成像和
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