Malhotra Manav, Sharma Rajiv, Sanduja Mohit, Kumar Rajeev, Jain Jainendra, Deep Aakash
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozepur Road, Moga-142 001, India.
Acta Pol Pharm. 2012 Mar-Apr;69(2):355-61.
In the present study, (E)-2-{ [-2-(2,4-Dinitrophenyl)hydrazono]methyl} phenol (3) was synthesized and used as key intermediate for the synthesis of new Mannich bases. All the synthesized compounds were evaluated for their antifungal activity against three fungal strains Candida albicans, Candida tropicalis and Aspergillus niger and antioxidant activity. The structure of these compounds was confirmed by IR, 1H NMR and 13C NMR studies. Most of the compounds exhibited moderate to significant activities.
在本研究中，合成了(E)-2-{[-2-(2,4-二硝基苯基)肼基]甲基}苯酚(3)，并将其用作合成新型曼尼希碱的关键中间体。对所有合成的化合物进行了针对白色念珠菌、热带念珠菌和黑曲霉三种真菌菌株的抗真菌活性以及抗氧化活性评估。通过红外光谱(IR)、氢核磁共振(1H NMR)和碳核磁共振(13C NMR)研究确定了这些化合物的结构。大多数化合物表现出中度至显著的活性。
