Malhotra Manav, Sharma Rajiv, Sanduja Mohit, Hans Pankhuri, Sharma Sagun, Deep Aakash
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozepur Road, Moga-142 001, India.
Acta Pol Pharm. 2012 Mar-Apr;69(2):363-8.
Seventeen analogues of benzylidene were synthesized and evaluated for in vitro hydrogen peroxide scavenging activity. The structure of the newly synthesized compounds were confirmed by elemental and spectral (IR, 1H-NMR, 13C-NMR) studies. The antioxidant activity of the titled compounds was evaluated. Compounds: 4h--N'-[2-amino-3-(morpholinomethyl)benzylidene]isonicotinohydrazide, 4p 7-(4-(2-amino-3-[(2-isonicotinoylhydrazono)methyl]benzyl}piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquino- line-3-carboxylic acid and 4q 7-(4-{2-amino-3-[(2 isonicotinoylhydrazono)methyl]benzyl} piperazin-1-yl)-1-ethyl-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid were the most active compounds with significant hydrogen peroxide scavenging activity.
合成了17种亚苄基类似物，并对其体外过氧化氢清除活性进行了评估。通过元素分析和光谱（红外光谱、1H-核磁共振、13C-核磁共振）研究确定了新合成化合物的结构。评估了标题化合物的抗氧化活性。化合物：4h - N'-[2-氨基-3-(吗啉甲基)亚苄基]异烟肼、4p 7-(4-(2-氨基-3-[(2-异烟酰肼基亚甲基)苄基]哌嗪-1-基)-1-环丙基-6-氟-4-氧代-1,4-二氢喹啉-3-羧酸和4q 7-(4-{2-氨基-3-[(2-异烟酰肼基亚甲基)苄基]哌嗪-1-基)-1-乙基-6,8-二氟-4-氧代-1,4-二氢喹啉-3-羧酸是具有显著过氧化氢清除活性的最具活性的化合物。
