Zhou Han, Chen Zhi-Bin, Tian Hui-Qin, Xu Xia, Wang Yong-Qing, Xing Guang-Qian, Cheng Lei
Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Acta Otolaryngol. 2012 Sep;132(9):938-43. doi: 10.3109/00016489.2012.675085. Epub 2012 May 8.
Elevated levels of hypoxia-inducible factor 1α (HIF-1α) in middle ear effusion may play an important role in the pathogenesis of bone conduction impairment associated with otitis media with effusion (OME). The mechanism may be related to the up-regulation of nitric oxide (NO) expression.
This study was undertaken to investigate the role of HIF-1α in the pathogenesis of sensorineural hearing loss associated with OME.
One hundred and eight OME patients were divided into two groups: OME without bone conduction impairment (group 1) and OME with bone conduction impairment (group 2). The levels of HIF-1α, NO, and quinolinic acid (QUIN) in the middle ear effusion and serum of these patients were investigated. The relationship between these factors and the bone conduction threshold (BCT) differences were analyzed.
The levels of HIF-1α and NO concentrations in the middle ear effusion were found to be significantly higher in group 2 than in group 1 (both p < 0.05). The OME patients' BCT differences at 4000 Hz were correlated with the levels of HIF-1α and the NO concentrations in the middle ear effusion. Furthermore, the HIF-1α levels were correlated with the levels of NO but not with the levels of QUIN in the effusion.
中耳积液中缺氧诱导因子1α（HIF-1α）水平升高可能在与分泌性中耳炎（OME）相关的骨传导障碍发病机制中起重要作用。其机制可能与一氧化氮（NO）表达上调有关。
本研究旨在探讨HIF-1α在与OME相关的感音神经性听力损失发病机制中的作用。
108例OME患者分为两组：无骨传导障碍的OME患者（第1组）和有骨传导障碍的OME患者（第2组）。检测这些患者中耳积液和血清中HIF-1α、NO和喹啉酸（QUIN）的水平。分析这些因素与骨传导阈值（BCT）差异之间的关系。
发现第2组中耳积液中HIF-1α和NO浓度水平显著高于第1组（均p<0.05）。OME患者在4000Hz时的BCT差异与中耳积液中HIF-1α水平和NO浓度相关。此外，积液中HIF-1α水平与NO水平相关，但与QUIN水平无关。
