Sone Michihiko, Kato Toshinari, Arao Harumi, Izawa Kazuhiro, Suzuki Yasuyuki, Ishida Kazuya, Nakashima Tsutomu
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Acta Otolaryngol. 2013 Jan;133(1):35-41. doi: 10.3109/00016489.2012.715374. Epub 2012 Sep 19.
The present study showed that elevation of bone-conduction (BC) thresholds at low frequencies might be a characteristic audiometric finding in cases with otitis media with effusion (OME) with high pepsinogen (PG) concentrations.
The objective of this study was to investigate whether there is any characteristic audiometric finding in adult cases with otitis media with high PG compared to those with low PG.
Twenty-four adult patients with unilateral OME of undetermined etiology and high PG concentrations (> 500 ng/ml) in their middle ear effusions (high PG group) were selected. The air-conduction and BC thresholds of pure tone audiometry were compared between the affected and healthy ears. Results were compared to those in 23 patients with low PG concentrations (< 50 ng/ml; low PG group).
The average BC difference in the threshold at 0.25 kHz between the affected ear and the healthy ear was significantly higher in the high PG group than in the low PG group, with a significantly higher proportion of patients in the high PG group having BC thresholds at 0.25 kHz in the affected ear that were ≥ 15 dB higher than in the healthy ear.
本研究表明，在中耳积液（OME）且胃蛋白酶原（PG）浓度高的病例中，低频骨导（BC）阈值升高可能是一种特征性听力检查结果。
本研究的目的是调查与低PG的成年中耳炎病例相比，高PG的成年中耳炎病例是否有任何特征性听力检查结果。
选择24例病因不明的单侧OME且中耳积液中PG浓度高（>500 ng/ml）的成年患者（高PG组）。比较患耳与健耳纯音听力测定的气导和BC阈值。结果与23例PG浓度低（<50 ng/ml；低PG组）的患者进行比较。
高PG组患耳与健耳在0.25 kHz处的平均BC阈值差异显著高于低PG组，高PG组中患耳在0.25 kHz处的BC阈值比健耳高≥15 dB的患者比例显著更高。
