Department of Otolaryngology–Head and Neck Surgery, The University of Ottawa, Ottawa, ON.
J Otolaryngol Head Neck Surg. 2012 Apr;41 Suppl 1:S13-20.
To test the hypothesis that using Listerine mouthwash prior to administration of topical nasal lidocaine will result in improved pain and comfort outcomes during flexible nasolaryngoscopy (FNL).
Randomized, controlled trial.
A total of 120 patients were randomized to receive a combination of either treatment or placebo mouthwash followed by treatment or placebo nasal spray prior to an FNL examination.
Pain and discomfort using a 100 mm visual analogue scale.
The use of lidocaine significantly reduced pain (p = .011) and discomfort (p = .008) compared to placebo nasal spray. Using Listerine prior to administration of lidocaine resulted in the largest reductions. Patients having an extended nasal examination reported more pain (p = .001) and discomfort (p = .03) levels while demonstrating a greater benefit of topical lidocaine compared to those undergoing a primary laryngeal examination (p < .001).
Using Listerine prior to application of lidocaine nasal spray reduces the pain and discomfort of FNL. This effect was most clinically significant in patients undergoing an extended or full bilateral nasal examination.
检验假设，即在使用利多卡因局部鼻喷雾剂之前使用李施德林漱口水是否会改善软性鼻咽喉镜检查（FNL）期间的疼痛和舒适度。
随机对照试验。
共有 120 名患者随机分为接受治疗或安慰剂漱口液组，然后在 FNL 检查前接受治疗或安慰剂鼻喷雾剂。
使用 100mm 视觉模拟量表测量疼痛和不适。
与安慰剂鼻喷雾剂相比，利多卡因的使用显著减轻了疼痛（p =.011）和不适（p =.008）。在给予利多卡因之前使用李施德林漱口水可产生最大的减轻效果。进行延长的鼻腔检查的患者报告的疼痛（p =.001）和不适（p =.03）水平更高，与仅进行喉部检查的患者相比，局部利多卡因的效果更显著（p <.001）。
在使用利多卡因鼻喷雾剂之前使用李施德林漱口水可减轻 FNL 的疼痛和不适。在进行延长或双侧鼻腔检查的患者中，这种效果最具有临床意义。
