of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, Ontario, Canada.
J Otolaryngol Head Neck Surg. 2010 Feb;39(1):96-101.
To test the hypothesis that using an alcohol-based, mint-flavoured oral mouthwash prior to applying oral lidocaine spray will result in an improvement in the unpleasant taste of the lidocaine.
A double-blind, randomized, controlled trial using a crossover design.
A tertiary care hospital.
Fifteen able-bodied volunteers rinsed for 30 seconds with either a mint-flavoured, alcohol-based mouthwash (treatment) or plain water (placebo) prior to the administration of topical lidocaine spray. All subjects received both the treatment and the placebo; however, the order of exposure was randomized.
Subjects completed two 100 mm visual analogue scales (VASs). The first assessed the overall satisfaction with the taste of the lidocaine. This consisted of a 100 mm VAS with 0 defined as the "most unpleasant taste" and 100 mm defined as the "most pleasant taste," whereas 50 mm was defined as neutral or no taste. The second VAS assessed subjective analgesia after lidocaine administration.
There was a statistically significant improvement in the taste of oral lidocaine after administering the treatment intervention (p = .003). There was a reduction in subjective analgesia, which did not reach statistical significance (p = .03). Use of the oral mouthwash reduced the perception of the negative flavour of the lidocaine from 20.77 (13.2) mm to 50.2 (12.84) mm as assessed by the VAS.
A brief rinse with a mint-flavoured, alcohol-based mouthwash prior to administration of topical lidocaine resulted in a significant improvement in the perceived flavour of topical lidocaine with a minimal reduction in subjective analgesia.
检验使用含酒精、薄荷味的口腔漱口液在使用口腔利多卡因喷雾前漱口是否会改善利多卡因的不良味道这一假说。
采用双盲、随机、对照试验，交叉设计。
一家三级保健医院。
15 名健康志愿者用含薄荷味、酒精的口腔漱口液（处理组）或清水（安慰剂）漱口 30 秒，然后再给予局部利多卡因喷雾。所有受试者均接受了处理组和安慰剂组的治疗；然而，暴露的顺序是随机的。
受试者完成了两个 100 毫米视觉模拟量表（VAS）。第一个评估了对利多卡因味道的总体满意度。这包括一个 100 毫米的 VAS，0 定义为“最不愉快的味道”，100 毫米定义为“最愉快的味道”，而 50 毫米定义为中性或无味道。第二个 VAS 评估了利多卡因给药后的主观镇痛效果。
在给予治疗干预后，口腔利多卡因的味道有统计学上的显著改善（p =.003）。主观镇痛效果有一定程度的降低，但没有达到统计学意义（p =.03）。使用口腔漱口液后，利多卡因的负面味道从 20.77（13.2）毫米降至 50.2（12.84）毫米，这是通过 VAS 评估得出的。
在局部利多卡因给药前用含酒精、薄荷味的口腔漱口液漱口 30 秒，可显著改善局部利多卡因的口感，同时主观镇痛效果略有降低。
