暴露于含有镍和其他有毒金属的工业空气污染人群的死亡率。
Mortality among population with exposure to industrial air pollution containing nickel and other toxic metals.
机构信息
Department of Environmental Health, National Institute for Health and Welfare, University of Eastern Finland, Kuopio, Finland.
出版信息
J Occup Environ Med. 2012 May;54(5):583-91. doi: 10.1097/JOM.0b013e3182492050.
OBJECTIVE
To assess disease mortality among people with exposure to metal-rich particulate air pollution.
METHODS
We conducted a cohort study on mortality from 1981 to 2005 among 33,573 people living near a nickel/copper smelter in Harjavalta, Finland. Nickel concentration in soil humus was selected as an indicator for long-term exposure. Relative risks--adjusted for age, socioeconomic status, and calendar period--were calculated for three exposure zones.
RESULTS
The relative risks for diseases of the circulatory system by increasing exposure were 0.93 (95% confidence interval = 0.79 to 1.09), 1.20 (1.04 to 1.39), and 1.18 (1.00 to 1.39) among men and 1.01 (0.88 to 1.17), 1.20 (1.04 to 1.38), and 1.14 (0.97 to 1.33) among women. Exclusion of smelter workers from the cohort did not materially change the results.
CONCLUSIONS
Long-term environmental exposure to metal-rich air pollution was associated with increased mortality from circulatory diseases.
目的
评估接触富含金属的颗粒物空气污染人群的疾病死亡率。
方法
我们对芬兰哈贾瓦尔塔（Harjavalta）一家镍/铜冶炼厂附近 33573 名居民在 1981 年至 2005 年间的死亡率进行了队列研究。土壤腐殖质中的镍浓度被选为长期暴露的指标。调整了年龄、社会经济地位和日历时间等因素后，计算了三个暴露区的相对风险。
结果
男性的循环系统疾病相对风险分别为 0.93（95%置信区间=0.79 至 1.09）、1.20（1.04 至 1.39）和 1.18（1.00 至 1.39），女性分别为 1.01（0.88 至 1.17）、1.20（1.04 至 1.38）和 1.14（0.97 至 1.33）。将冶炼厂工人从队列中排除并没有实质性地改变结果。
结论
长期暴露于富含金属的空气污染环境与循环系统疾病死亡率增加有关。
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