内皮素激活大鼠肠系膜动脉中的血管肾素-血管紧张素系统。

Endothelin activates the vascular renin-angiotensin system in rat mesenteric arteries.

作者信息

Rakugi H, Tabuchi Y, Nakamaru M, Nagano M, Higashimori K, Mikami H, Ogihara T

机构信息

Department of Geriatric Medicine, Osaka University Medical School, Japan.

出版信息

Biochem Int. 1990 Aug;21(5):867-72.

PMID:2256949

Abstract

The effects of endothelin on the vascular renin-angiotensin system were examined in isolated perfused rat mesenteric arteries by measuring vascular renin activity and angiotensin II released into the perfusate. Infusion of endothelin (10(-9)M and 10(-11)M) increased the vascular renin activity and angiotensin II release. Pretreatment with nicardipine (10(-6)M), a calcium channel blocker, significantly suppressed these effects of endothelin. These results suggest that endothelin activates the vascular renin-angiotensin system via intracellular calcium metabolism. Vascular angiotensin II produced by endothelin may modulate the local effect of endothelin on the resistance vessels.

摘要

通过测量血管肾素活性以及释放到灌注液中的血管紧张素II，在离体灌注的大鼠肠系膜动脉中研究了内皮素对血管肾素-血管紧张素系统的影响。输注内皮素（10^(-9)M和10^(-11)M）可增加血管肾素活性和血管紧张素II的释放。用钙通道阻滞剂尼卡地平（10^(-6)M）预处理可显著抑制内皮素的这些作用。这些结果表明，内皮素通过细胞内钙代谢激活血管肾素-血管紧张素系统。内皮素产生的血管血管紧张素II可能调节内皮素对阻力血管的局部作用。