Kofler B, Uecker F C, Muenscher A, Knecht R
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Hamburg-Eppendorf.
HNO. 2012 May;60(5):404-7. doi: 10.1007/s00106-011-2465-y.
HPV-positive head and neck carcinoma is significantly different than tobacco- and alcohol-induced cancer. Between 30% and 50% of oropharyngeal cancers are associated with human papillomavirus (HPV). Studies still show an increasing incidence. HPV-positive head and neck cancer patients have a better prognosis due to a better response to therapy. Especially patients with gene overexpression of immunological proteins in the antigen presentation are suggested to benefit from radiotherapy. A current retrospective study shows better outcomes for patients treated with radiotherapy in combination with biological targets compared to radiochemotherapy.
人乳头瘤病毒（HPV）阳性的头颈癌与烟草和酒精诱发的癌症有显著差异。30%至50%的口咽癌与人乳头瘤病毒（HPV）有关。研究仍显示其发病率在上升。HPV阳性的头颈癌患者对治疗反应较好，因此预后更佳。特别是那些在抗原呈递中存在免疫蛋白基因过表达的患者，放疗可能对其有益。一项近期的回顾性研究表明，与放化疗相比，接受放疗联合生物靶点治疗的患者预后更好。
