Department of Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
East Mediterr Health J. 2012 Feb;18(2):132-6. doi: 10.26719/2012.18.2.132.
The aim of this cross-sectional study in Jordan was to estimate the prevalence of hypothyroidism among women during early pregnancy and to assess the association of risk factors with hypothyroidism. According to internationally adopted thyroid stimulating hormone (TSH) and thyroxine (T4) pregnancy reference ranges (TSH > or = 2.6 mlU/L and T4 10.6-20.4 pmol/L), 67 of 322 (20.8%) women were diagnosed with sub-clinical hypothyroidism. When the general laboratory criteria were applied (TSH > or = 4.6 mlU/L and T4 < 10.6 pmol/L) the prevalence dropped to 4.3%. No cases of overt hypothyroidism were diagnosed using either diagnostic criterion. Younger age and being in gestational weeks 1-8 were significant risk factors for hypothyroidism. It is suggested that the reference criteria need revision, and that pathology laboratories should adopt appropriate pregnancy-specific reference intervals.
本研究旨在评估约旦早孕期女性亚临床甲状腺功能减退症的患病率，并分析其与各种危险因素的相关性。根据国际上采用的促甲状腺激素（TSH）和甲状腺素（T4）妊娠参考范围（TSH≥2.6mlU/L 和 T4 10.6-20.4pmol/L），322 例孕妇中有 67 例（20.8%）被诊断为亚临床甲状腺功能减退症。而采用一般实验室标准（TSH≥4.6mlU/L 和 T4＜10.6pmol/L）时，患病率则降至 4.3%。两种诊断标准均未发现显性甲状腺功能减退症病例。年龄较轻和妊娠 1-8 周是亚临床甲状腺功能减退症的显著危险因素。建议修订参考标准，同时建议病理实验室采用适合妊娠的特异性参考区间。
