Ezzeddine Dima, Ezzeddine Diala, Hamadi Caroline, Abbas Hussein A, Nassar Anwar, Abiad May, Ghazeeri Ghina
Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
School of Medicine, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
J Endocr Soc. 2017 Mar 22;1(5):415-422. doi: 10.1210/js.2017-00014. eCollection 2017 May 1.
Assessment of hypothyroidism prevalence and clinical significance among pregnant women in Lebanon.
We performed a single-center retrospective cohort study at the American University of Beirut Medical Center. Clinical, demographic, and laboratory data were collected and analyzed using trimester-specific ranges for hypothyroidism.
Of 920 pregnant women, 17% had hypothyroidism during gestation. A history of previous miscarriage and morbid obesity were associated with hypothyroidism during pregnancy. Pregnant women with hypothyroidism were more likely to experience a miscarriage during the first trimester [odds ratio, 2.9; 95% confidence interval, (1.13 to 7.5); = 0.02] and delivery at post-term (odds ratio, 3.9; 95% confidence interval, 1.05 to 14.9; = 0.05). We found no substantial correlation with preterm or premature delivery, cesarean section delivery, or gestational hypertension despite increased odds among the hypothyroidism group. No substantial differences were found with respect to the fetal outcomes between the control and hypothyroidism groups.
Hypothyroidism is prevalent in 17% of pregnant women in Lebanon and was associated with a history of miscarriage and morbid obesity. The presence of hypothyroidism correlated with miscarriage during the first trimester and with post-term delivery. Despite the lack of sufficient data supporting the efficacy of treatment of hypothyroidism during gestation, more studies should be conducted to assess the effect of hypothyroidism on gestational and fetal outcomes.
评估黎巴嫩孕妇甲状腺功能减退症的患病率及其临床意义。
我们在贝鲁特美国大学医疗中心开展了一项单中心回顾性队列研究。收集临床、人口统计学和实验室数据，并使用甲状腺功能减退症特定孕期范围进行分析。
在920名孕妇中，17%在妊娠期患有甲状腺功能减退症。既往流产史和病态肥胖与孕期甲状腺功能减退症相关。患有甲状腺功能减退症的孕妇在孕早期更易发生流产[比值比，2.9；95%置信区间，(1.13至7.5)；P = 0.02]，且过期分娩的可能性更大(比值比，3.9；95%置信区间，1.05至14.9；P = 0.05)。尽管甲状腺功能减退症组的几率有所增加，但我们未发现与早产、剖宫产或妊娠期高血压有显著相关性。对照组和甲状腺功能减退症组在胎儿结局方面未发现显著差异。
甲状腺功能减退症在黎巴嫩17%的孕妇中普遍存在，且与流产史和病态肥胖相关。甲状腺功能减退症与孕早期流产和过期分娩相关。尽管缺乏足够数据支持妊娠期甲状腺功能减退症治疗的有效性，但应开展更多研究以评估甲状腺功能减退症对妊娠和胎儿结局的影响。
