Department of Clinical Pharmacy, School of Pharmacy,Tehran University of Medical Sciences, Tehran, Islamic Republic of lran.
East Mediterr Health J. 2012 Feb;18(2):172-7. doi: 10.26719/2012.18.2.172.
The emergence of antimicrobial resistance is a global problem in the community and in hospitals. Antibiotic resistance of Gram-negative bacteria from nosocomial infections were evaluated during a 6-month period at Shariati teaching hospital, Tehran, Islamic Republic of Iran. Susceptibility tests were performed on 570 Gram-negative isolates obtained from clinical samples of patients infected after at least 72 hours stay in the hospital. Escherichia coli was the most frequently isolated Gram-negative organism (42.6%). The highest rate of resistance in Gram-negative isolates was seen in the intensive care unit, with Acinetobacter spp. as the most resistant organisms. Gentamicin was the most effective antibiotic against E. coli and all other isolates, while ciprofloxacin was also effective against a wide range of other species. Antibiotic resistant Gram-negative nosocomial infection is prevalent in this teaching hospital in Tehran.
抗微生物药物耐药性的出现是社区和医院的全球性问题。在伊朗德黑兰沙里亚蒂教学医院进行了为期 6 个月的研究，评估了医院获得性感染中革兰氏阴性菌的抗生素耐药性。对至少住院 72 小时后感染的患者的临床样本中分离出的 570 株革兰氏阴性菌进行了药敏试验。大肠埃希菌是最常分离的革兰氏阴性菌（42.6%）。在重症监护病房中，革兰氏阴性菌的耐药率最高，耐碳青霉烯类鲍曼不动杆菌是最耐药的细菌。庆大霉素是针对大肠杆菌和其他所有分离株最有效的抗生素，而环丙沙星也对多种其他菌株有效。在这家德黑兰的教学医院，革兰氏阴性菌的医院获得性感染普遍存在抗生素耐药性。
