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破裂性腹主动脉瘤血管内修复成功后的有利出院处置和生存。

Favorable discharge disposition and survival after successful endovascular repair of ruptured abdominal aortic aneurysm.

机构信息

Division of Vascular Surgery, University of Washington School of Medicine, Seattle, Wash, USA.

出版信息

J Vasc Surg. 2013 Jun;57(6):1495-502. doi: 10.1016/j.jvs.2012.11.089.

Abstract

OBJECTIVE

Endovascular repair of ruptured abdominal aortic aneurysm (rEVAR) has been shown to improve perioperative outcomes compared with open surgical repair (OSR). Follow-up of these patients, however, is lacking. In this study, we compare the discharge disposition and midterm survival of ruptured aneurysm patients who survived treatment with either rEVAR or OSR.

METHODS

We performed an institutional review board-approved, single-institution, retrospective review of all patients with ruptured abdominal aortic aneurysms (rAAAs) admitted from July 2007 to February 2012. Primary outcomes were discharge disposition and midterm survival (>30 days after the index operation). We also evaluated compliance with follow-up and prevalence of endoleak.

RESULTS

A total of 118 patients were analyzed. Eight patients received only comfort care, 10 died in the operating room, 39 underwent OSR, and 61 had rEVAR. Average age and sex were similar (OSR, 77 ± 7.8 years, 85% male; rEVAR, 74 ± 7.4 years, 79% male). Seventy-two survived to discharge (54% OSR [21/39]; 84% rEVAR [51/61]; P = .001). OSR patients had longer lengths of intensive care unit and total length of stay than rEVAR (11.8 ± 10.4/23 ± 16.4 days vs 6.3 ± 8.5/12.3 ± 13.0 days; P = .002/.02). Only 19% (4/21) of patients were discharged home after OSR, rather than to a skilled nursing facility. Significantly more rEVAR patients were discharged to home rather than a skilled nursing facility (65%; 33/51) (P = .0004). Overall, the follow-up rate for determination of survival for patients who lived past 30 days was 86% (56/65; median, 14 months; 25th-75th interquartile, 3.1-27.8). Multivariable logistic regression revealed only the type of procedure performed and perioperative hypotension predicted discharge destination. Kaplan-Meier analysis revealed a significant midterm survival benefit for patients after rEVAR compared with OSR (P = .01, log-rank). Subgroup analysis of survivors past 30 days revealed similar rates of midterm survival (P = .7, log-rank). Overall, midterm relative risk reduction for death after rEVAR vs OSR was 35% (95% confidence interval, 0.06-0.59).

CONCLUSIONS

We have previously demonstrated that successful utilization of rEVAR improves the early survival of rAAA patients compared with OSR. This study shows that more patients are able to be discharged to home after rEVAR and that the early survival advantage is continued in midterm follow-up, suggesting that rEVAR should be attempted first when feasible. Further studies are needed to determine the long-term durability of endovascular repair in the management of rAAA as well as the impact on cost and long-term quality of life.

摘要

目的

与开放手术修复(OSR)相比,血管内修复破裂的腹主动脉瘤(rEVAR)已显示出可改善围手术期结果。然而,这些患者的随访情况尚不清楚。在这项研究中,我们比较了接受 rEVAR 或 OSR 治疗后存活的破裂性动脉瘤患者的出院去向和中期生存情况。

方法

我们对 2007 年 7 月至 2012 年 2 月期间因破裂性腹主动脉瘤(rAAA)入院的所有患者进行了机构审查委员会批准的单中心回顾性研究。主要结局是出院去向和中期生存(指数手术后 30 天以上)。我们还评估了随访的依从性和内漏的发生率。

结果

共分析了 118 例患者。8 例仅接受了舒适护理,10 例在手术室死亡,39 例行 OSR,61 例行 rEVAR。平均年龄和性别相似(OSR,77±7.8 岁,85%男性;rEVAR,74±7.4 岁,79%男性)。72 例患者存活至出院(OSR 组 54%[21/39];rEVAR 组 84%[51/61];P=0.001)。OSR 患者的重症监护病房和总住院时间长于 rEVAR(11.8±10.4/23±16.4 天 vs 6.3±8.5/12.3±13.0 天;P=0.002/.02)。OSR 后仅有 19%(4/21)的患者出院回家,而非疗养院。rEVAR 患者出院回家的比例明显更高(65%;33/51)(P=0.0004)。总体而言,在术后 30 天存活的患者中,确定生存情况的随访率为 86%(56/65;中位数,14 个月;25%至 75%分位数,3.1-27.8)。多变量逻辑回归显示,只有手术类型和围手术期低血压预测了出院去向。Kaplan-Meier 分析显示,rEVAR 患者的中期生存获益明显优于 OSR(P=0.01,对数秩检验)。对存活超过 30 天的患者进行亚组分析显示,中期生存率相似(P=0.7,对数秩检验)。总体而言,rEVAR 与 OSR 相比,死亡的中期相对风险降低了 35%(95%置信区间,0.06-0.59)。

结论

我们之前已经证明,成功应用 rEVAR 可改善 rAAA 患者的早期生存率,优于 OSR。本研究表明,rEVAR 后更多的患者能够出院回家,并且早期生存优势在中期随访中得以持续,这表明在可行的情况下,应首先尝试 rEVAR。需要进一步的研究来确定血管内修复在破裂性腹主动脉瘤管理中的长期耐久性以及对成本和长期生活质量的影响。

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