Academic Vascular Surgical Unit, University of Hull & Hull York Medical School, Hull, United Kingdom.
Department of Vascular Surgery, Hull Royal Infirmary, Hull, United Kingdom.
Angiology. 2020 Aug;71(7):626-632. doi: 10.1177/0003319720911578. Epub 2020 Mar 13.
We investigated factors that affected perioperative, postoperative, and long-term outcomes of patients who underwent open emergency surgical repair of ruptured abdominal aortic aneurysms (RAAA). All patients who underwent open emergency surgical repair from 1990 to 2011 were included (463 patients; 374 [81%] male; mean age 74.7 ± 8.7years). Logistic and Cox regression analyses were performed to explore the association of variables with outcomes. Preoperatively, median (interquartile range) hemoglobin was 11.2 (9.5-12.8) g/dL, and median creatinine level was 140 (112-177) µmol/L. Intraoperatively, the median operative time was 2.25 (2-3) hours, and median estimated blood loss was 1.5 (0.5-3) L; 250 (54%) patients required intraoperative inotropes, and a median of 6 (4-8) units of blood was transfused. Median length of hospital stay was 11 (7-20) days. In-hospital mortality rate was 35.6%, and 5-year mortality was 48%. Age, distance traveled, operation duration, postoperative myocardial infarction (MI), and multi-organ failure (MOF) were predictors of in-hospital mortality and long-term outcome. Additionally, postoperative acute renal failure predicted in-hospital mortality. In patients with RAAA undergoing open surgical repair, the strongest predictors of in-hospital mortality and long-term outcome were postoperative MOF and MI and operative duration.
我们研究了影响接受开放性急诊手术修复破裂腹主动脉瘤(RAAA)患者围手术期、术后和长期结局的因素。纳入了 1990 年至 2011 年期间接受开放性急诊手术修复的所有患者(463 例;374 例[81%]为男性;平均年龄 74.7±8.7 岁)。进行了逻辑和 Cox 回归分析,以探讨变量与结局的关联。术前中位数(四分位距)血红蛋白为 11.2(9.5-12.8)g/dL,中位数肌酐水平为 140(112-177)µmol/L。术中中位数手术时间为 2.25(2-3)小时,中位数估计出血量为 1.5(0.5-3)L;250(54%)例患者需要术中正性肌力药,中位数输注 6(4-8)单位的血液。中位住院时间为 11(7-20)天。院内死亡率为 35.6%,5 年死亡率为 48%。年龄、旅行距离、手术时间、术后心肌梗死(MI)和多器官衰竭(MOF)是院内死亡率和长期结局的预测因素。此外,术后急性肾衰竭预测院内死亡率。在接受开放性手术修复的 RAAA 患者中,院内死亡率和长期结局的最强预测因素是术后 MOF 和 MI 以及手术时间。