几种与脂质相关的基因多态性与白裤瑶人群血压变化的关联。

Association of several lipid-related gene polymorphisms and blood pressure variation in the Bai Ku Yao population.

机构信息

Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, People's Republic of China.

出版信息

Am J Hypertens. 2012 Aug;25(8):927-36. doi: 10.1038/ajh.2012.55. Epub 2012 May 10.

DOI:10.1038/ajh.2012.55

PMID:22573014

Abstract

BACKGROUND

Sex differences in hypertension are not well known. The present study was undertaken to detect the association of nine lipid-related gene polymorphisms and blood pressure variation beween men and women in the Bai Ku Yao population.

METHODS

Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low-density lipoprotein receptor (LDL-R) AvaII, hepatic lipase gene (LIPC) -250G>A, endothelial lipase gene (LIPG) 584C>T, methylenetetrahydrofolate reductase (MTHFR) 677C>T, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T>C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 682 normotensives and 670 hypertensives.

RESULTS

The genotypic frequencies of LDL-R and SCARB1 in normotensives and ABCA-1, ACAT-1, LDL-R, LIPC, and MTHFR in hypertensives were different between males and females (P < 0.05-0.001). The genotypic frequencies of ABCA-1, ACAT-1, LDL-R, LIPC, MTHFR, PPARD, and SCARB1 in males and ABCA-1, LDL-R, LIPC, LIPG, and MTHFR in females were different between normotensives and hypertensives (P < 0.05-0.001). Systolic blood pressure (SBP) levels in male hypertensives were different among the LIPC, LIPG, PCSK9, and SCARB1 genotypes (P < 0.05-0.01); and diastolic blood pressure (DBP) levels were different among the ABCA-1, LDL-R, LIPC, LIPG, MTHFR, PCSK9, and PPARD genotypes (P < 0.05-0.001). SBP levels in female hypertensives were different among the LIPC, MTHFR, PCSK9, and PPARD genotypes (P < 0.05-0.01); and DBP levels were different among ABCA-1, ACAT-1, MTHFR, PCSK9, PPARD, and SCARB1 genotypes (P <0.05-0.001). The correlations between these polymorphisms and blood pressure levels were also observed.

CONCLUSIONS

Sex differences in blood pressure levels in this population may partly attribute to the differences in some lipid-related gene polymorphisms.

摘要

背景

高血压存在性别差异，但目前人们对此了解甚少。本研究旨在探讨白裤瑶人群中 9 个与血脂相关的基因多态性与男女血压变异之间的关系。

方法

对载脂蛋白 ABCA1（ABCA-1）V825I、酰基辅酶 A：胆固醇酰基转移酶-1（ACAT-1）rs1044925、低密度脂蛋白受体（LDL-R）AvaII、肝脂肪酶基因（LIPC）-250G>A、内皮脂肪酶基因（LIPG）584C>T、亚甲基四氢叶酸还原酶（MTHFR）677C>T、前蛋白转化酶枯草溶菌素 9（PCSK9）E670G、过氧化物酶体增殖物激活受体δ（PPARD）+294T>C 和清道夫受体 B 型 1（SCARB1）rs5888 进行基因分型，共纳入 682 名血压正常者和 670 名高血压患者。

结果

血压正常者中 LDL-R 和 SCARB1 基因型频率以及高血压患者中 ABCA-1、ACAT-1、LDL-R、LIPC 和 MTHFR 基因型频率在男女之间存在差异（P<0.05-0.001）。男性中 ABCA-1、ACAT-1、LDL-R、LIPC、MTHFR、PPARD 和 SCARB1 基因型以及女性中 ABCA-1、LDL-R、LIPC、LIPG 和 MTHFR 基因型在血压正常者和高血压患者之间存在差异（P<0.05-0.001）。男性高血压患者中 LIPC、LIPG、PCSK9 和 SCARB1 基因型的收缩压（SBP）水平存在差异（P<0.05-0.01）；女性高血压患者中 ABCA-1、LDL-R、LIPC、LIPG、MTHFR、PCSK9 和 PPARD 基因型的舒张压（DBP）水平存在差异（P<0.05-0.001）。女性高血压患者中 LIPC、MTHFR、PCSK9 和 PPARD 基因型的 SBP 水平存在差异（P<0.05-0.01）；女性高血压患者中 ABCA-1、ACAT-1、MTHFR、PCSK9、PPARD 和 SCARB1 基因型的 DBP 水平存在差异（P<0.05-0.001）。还观察到这些多态性与血压水平之间的相关性。