Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Eye (Lond). 2012 May;26(5):640-9. doi: 10.1038/eye.2012.66.
To prospectively compare the effects of half-dose verteporfin (3 mg/m(2)) photodynamic therapy (1/2 PDT) with those of one-third-dose verteporfin (2 mg/m(2)) PDT (1/3 PDT) for chronic central serous chorioretinopathy (CSC).
Sixteen eyes of 16 consecutive patients with chronic CSC were enrolled and followed up for a 3-month study period. The first 10 patients received 1/2 PDT and the next 6 patients received 1/3 PDT. The resolution rate of subretinal fluid (SRF) was compared between the two groups. The changes in the choroidal thickness inside and outside the PDT-applied area in both groups were also evaluated.
SRF disappeared in all eyes (100%) in the 1/2 PDT group and in two eyes (33%) in the 1/3 PDT group. In the 1/2 PDT group, choroidal thickness inside and outside the PDT-applied area reduced significantly from the baseline (inside, from 387 ± 24 to 325 ± 25 μm; outside, from 292 ± 25 to 249 ± 19 μm; both P=0.005). In the 1/3 PDT group, choroidal thickness decreased in two eyes where SRF disappeared (inside, 87.2 and 90.9% of the baseline; outside, 91.4 and 92.6% of the baseline), but did not change in the other four eyes where SRF remained (inside, 104.1, 100.0, 105.1, and 100.5% of the baseline; outside, 98.9, 103.0, 100.0, and 99.0% of the baseline).
1/2 PDT is more effective than 1/3 PDT in the resolution of SRF for chronic CSC. Decrease in the choroidal thickness after PDT may be related to the resolution of SRF in chronic CSC.
前瞻性比较半剂量（3mg/m2）维替泊芬光动力疗法（1/2 PDT）与三分之一剂量（2mg/m2）维替泊芬光动力疗法（1/3 PDT）治疗慢性中心性浆液性脉络膜视网膜病变（CSC）的疗效。
纳入 16 例（16 只眼）连续的慢性 CSC 患者，进行为期 3 个月的研究随访。前 10 例患者接受 1/2 PDT，后 6 例患者接受 1/3 PDT。比较两组患者的视网膜下液（SRF）消退率。评估两组 PDT 治疗区域内外脉络膜厚度的变化。
1/2 PDT 组所有患者（100%）的 SRF 均完全消退，而 1/3 PDT 组仅有 2 例患者（33%）的 SRF 消退。1/2 PDT 组 PDT 治疗区域内和外的脉络膜厚度从基线水平显著降低（内侧，从 387±24μm降至 325±25μm；外侧，从 292±25μm降至 249±19μm；均 P=0.005）。在 1/3 PDT 组，SRF 消退的 2 只眼的脉络膜厚度下降（内侧分别为基线的 87.2%和 90.9%，外侧分别为基线的 91.4%和 92.6%），但 SRF 仍存在的另外 4 只眼的脉络膜厚度无变化（内侧分别为基线的 104.1%、100.0%、105.1%和 100.5%，外侧分别为基线的 98.9%、103.0%、100.0%和 99.0%）。
1/2 PDT 在治疗慢性 CSC 的 SRF 消退方面比 1/3 PDT 更有效。PDT 后脉络膜厚度的下降可能与慢性 CSC 中 SRF 的消退有关。
