Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Charité-Universitätsmedizin, Berlin, Germany.
Skin Pharmacol Physiol. 2012;25(4):182-91. doi: 10.1159/000337933. Epub 2012 May 4.
BACKGROUND/AIMS: Inconsistent evidence is available that different ethnic groups exhibit differences in skin physiological parameters. Recently, variations in hair follicle morphology have been described, although the influence of such variations on the follicular penetration process has not been investigated until now.
The aim of the present study was thus to investigate skin physiological parameters, follicle morphology and the penetration process in different ethnic groups.
Whereas no significant differences with regard to skin physiological parameters could be observed, morphological analysis of the hair follicles revealed, inter alia, that Caucasians had significantly larger terminal hair follicles than Asians and Africans. The surface of the hair follicle infundibulum was shown to be 3% in Caucasians, 2.6% in Africans and 2.4% in Asians. The investigations into penetration revealed no significant differences after a 30-min penetration time, whereas after 24 h, the Asian volunteers presented significantly larger amounts of sodium fluorescein in the hair follicles and the stratum corneum, which may be explained by cultural habits.
背景/目的：不同种族之间的皮肤生理参数存在差异，这方面的证据并不一致。最近，毛囊形态的变化已经被描述出来，尽管这些变化对毛囊穿透过程的影响尚未被研究。
因此，本研究的目的是研究不同种族之间的皮肤生理参数、毛囊形态和穿透过程。
虽然在皮肤生理参数方面没有观察到显著差异，但毛囊的形态分析表明，白种人的终毛毛囊明显大于亚洲人和非洲人。毛囊漏斗部的表面面积在白种人中为 3%，在非洲人中为 2.6%，在亚洲人中为 2.4%。穿透研究发现，30 分钟的穿透时间后没有显著差异，而 24 小时后，亚洲志愿者的毛囊和角质层中含有明显更多的荧光素钠，这可以用文化习惯来解释。
