Raymond S A, Thalhammer J G, Popitz-Bergez F, Strichartz G R
Anesthesia Research Laboratories, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115.
Brain Res. 1990 Sep 3;526(2):318-21. doi: 10.1016/0006-8993(90)91239-d.
Conduction velocity was measured in vivo in single cutaneous afferent fibers of rat sciatic nerve that were characterized by natural stimulation. During sustained electrical stimulation, impulses slowed less and propagated more reliably in cold fibers (both A delta and C) than in nociceptive fibers of similar conduction velocity. Velocity in cold fibers tended to stabilize after an initial decrease rather than decrease throughout the stimulation as for nociceptive fibers. The slowing correlated with axon modality and hence with natural firing pattern, raising the possibility that impulse activity can determine conduction properties of axons.
在体测量了大鼠坐骨神经单根皮传入纤维的传导速度，这些纤维通过自然刺激进行表征。在持续电刺激期间，冷觉纤维（Aδ和C类）中的冲动减慢较少，且比传导速度相似的伤害性纤维传播更可靠。冷觉纤维的速度在最初下降后趋于稳定，而不像伤害性纤维那样在整个刺激过程中持续下降。这种减慢与轴突类型相关，因此也与自然放电模式相关，这增加了冲动活动可以决定轴突传导特性的可能性。
