通过酰胺-苯炔-[2 + 2]环加成级联反应的全合成方法制备石蒜裂碱和去甲石蒜裂碱。
Total syntheses of chelidonine and norchelidonine via an enamide-benzyne-[2 + 2] cycloaddition cascade.
机构信息
Department of Chemistry and Division of Pharmaceutical Sciences, University of Wisconsin, Madison, Wisconsin 53705, USA.
出版信息
Org Lett. 2012 Jun 1;14(11):2742-5. doi: 10.1021/ol300967a. Epub 2012 May 10.
Abstract
Total syntheses of chelidonine and norchelidonine featuring an enamide-benzyne-[2 + 2] cycloaddition initiated cascade is described. The cascade includes a pericyclic ring-opening and intramolecular Diels-Alder reaction.
摘要
本文描述了以烯酰胺-苯炔[2+2]环加成引发的级联反应为特色的Chelidonine 和 Norchelidonine 的全合成。该级联反应包括周环开环和分子内 Diels-Alder 反应。
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