Wang Xin-Hua, Huang Cong-Xin, Liu Xu, Shi Hai-Feng, Tan Hong-Wei, Jiang Wei-Feng, Wang Yuan-Long
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
J Interv Card Electrophysiol. 2012 Oct;35(1):45-56. doi: 10.1007/s10840-012-9678-1. Epub 2012 May 11.
The purpose of this study is to investigate the mechanism and the effectiveness of ablation of atrial tachycardia (AT) recurring after atrial fibrillation (AF) ablation in patients with rheumatic valvular disease (RVD) and mitral valve prosthesis.
Twenty-eight consecutive patients with RVD and mitral valve prosthesis and a 1:2 matched control group (n = 56) without RVD underwent reablation for recurrent AT after catheter ablation of long-standing persistent AF.
Macro- or localized reentrant ATs were identified in 47 (87 %) of 54 ATs from RVD group and in 65 (78.3 %) of 83 ATs from control. There were more average ATs per patient in the RVD group than in the control (1.9 ± 0.6 vs.1.5 ± 0.6, P = 0.002). The proportion of patients having ≥2 ATs was significantly higher in the RVD group than in the control (78.6 vs.41.1 %, P = 0.001). In the RVD group, ATs were successfully ablated in 44 (81.5 %) of 54 ATs and terminated in 18 (64.3 %) of 28 patients. In the control, ATs were successfully ablated in 72 (86.7 %) of 83 ATs and terminated in 45 (80.4 %) of 56 patients, P = 0.54 and 0.10, respectively. After a mean follow-up of 13 months, 16 patients (57.1 %) from the RVD group and 45 patients (80.4 %) from the control were free of further recurrence, P = 0.02.
Macro- or localized reentries were the predominant type of recurrent AT after long-standing persistent AF ablation in both the RVD and the control groups. Compared with patients without RVD, patients with RVD had more average number of ATs and had higher probability of further recurrence despite the similar acute effectiveness of reablation.
本研究旨在探讨风湿性瓣膜病(RVD)合并二尖瓣人工瓣膜患者房颤(AF)消融术后复发房性心动过速(AT)的机制及消融效果。
28例连续的RVD合并二尖瓣人工瓣膜患者及1:2匹配的无RVD对照组(n = 56)在导管消融长期持续性房颤后因复发性AT接受再次消融。
RVD组54例AT中的47例(87%)及对照组83例AT中的65例(78.3%)被确定为大折返或局灶性折返性AT。RVD组患者平均AT数多于对照组(1.9±0.6 vs.1.5±0.6,P = 0.002)。RVD组中≥2次AT的患者比例显著高于对照组(78.6% vs.41.1%,P = 0.001)。在RVD组,54例AT中的44例(81.5%)成功消融,28例患者中的18例(64.3%)AT终止。在对照组,83例AT中的72例(86.7%)成功消融,56例患者中的45例(80.4%)AT终止,P分别为0.54和0.10。平均随访13个月后,RVD组16例患者(57.1%)及对照组45例患者(80.4%)无进一步复发,P = 0.02。
大折返或局灶性折返是RVD组和对照组长期持续性房颤消融术后复发性AT的主要类型。与无RVD患者相比,RVD患者平均AT数更多且尽管再次消融的急性效果相似但进一步复发的可能性更高。