State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
J Biomed Mater Res B Appl Biomater. 2012 Jul;100(5):1257-63. doi: 10.1002/jbm.b.32690. Epub 2012 May 11.
This study sought to prepare a calcium silicate cement (CSC) with varying additions of tricalcium aluminate (Ca(3)Al(2)O(6), C(3)A), and to find an optimal amount of C(3)A by evaluating the effect of C(3)A on the physicochemical and in vitro biological properties of the CS/C(3)A cement. The results indicated that the addition of C(3)A into CSC reduced the setting time and improved the compressive strength especially at the early stage of setting. However, the 15% C(3)A was too much for the CS/C(3)A system and did harm to its strength development. Furthermore, the CS/C(3)A cement was bioactive and biocompatible in vitro, and had a stimulatory effect on the cell growth, when the content of C(3)A was 5 or 10%. When compared with the commercially available Dycal(®), the CS/C(3)A cement was notably more compatible with the human dental pulp cells. Therefore, the CS/C(3)A cement with 5-10% C(3)A produced the best compromise between setting and in vitro biological properties, and may be a promising candidate for endodontic use.
本研究旨在制备不同掺量铝酸三钙（Ca(3)Al(2)O(6)，C(3)A）的硅酸钙水泥（CSC），并通过评估 C(3)A 对 CS/C(3)A 水泥物理化学和体外生物学性能的影响，寻找最佳的 C(3)A 掺量。结果表明，C(3)A 的加入降低了 CSC 的凝结时间，提高了其抗压强度，尤其是在凝结的早期阶段。然而，15%的 C(3)A 对 CS/C(3)A 体系来说太多了，会对其强度发展造成损害。此外，CS/C(3)A 水泥在体外具有生物活性和生物相容性，当 C(3)A 的含量为 5%或 10%时，对细胞生长有刺激作用。与市售的 Dycal(®)相比，CS/C(3)A 水泥与人类牙髓细胞明显更相容。因此，CS/C(3)A 水泥中掺加 5-10%的 C(3)A 在凝结和体外生物学性能之间取得了最佳的平衡，可能是一种有前途的牙髓内使用的候选材料。
