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2
The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia.美国血液学会 2011 年免疫性血小板减少症循证实践指南。
Blood. 2011 Apr 21;117(16):4190-207. doi: 10.1182/blood-2010-08-302984. Epub 2011 Feb 16.
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Persistently raised plasma levels of platelet-derived inflammatory mediators in HIV-infected patients during highly active anti-retroviral therapy.在高效抗逆转录病毒治疗期间，HIV感染患者血浆中血小板衍生的炎症介质水平持续升高。
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HIV-1 Tat-induced platelet activation and release of CD154 contribute to HIV-1-associated autoimmune thrombocytopenia.HIV-1 Tat 诱导的血小板活化和 CD154 的释放导致 HIV-1 相关自身免疫性血小板减少症。
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Romiplostim or standard of care in patients with immune thrombocytopenia.罗米司亭或标准治疗用于免疫性血小板减少症患者。
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Pathogenic mechanisms of HIV disease.HIV 疾病的发病机制。
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The treatment of patients with HIV.HIV 感染者的治疗。
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HIV和SIV相关性血小板减少症：血小板在HIV发病机制中的作用不断扩大

HIV and SIV Associated Thrombocytopenia: An Expanding Role for Platelets in the Pathogenesis of HIV.

作者信息

Metcalf Pate Kelly A, Mankowski Joseph L

机构信息

Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore MD, 21205.

出版信息

Drug Discov Today Dis Mech. 2011 Summer;8(1-2):e25-e32. doi: 10.1016/j.ddmec.2011.10.001. Epub 2011 Nov 9.

DOI:10.1016/j.ddmec.2011.10.001
PMID:22577463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3346281/
Abstract

Thrombocytopenia is common in HIV and SIV infection, and is often associated with disease progression. HIV and SIV-associated thrombocytopenia arise through multiple mechanisms, including decreased platelet production, increased platelet destruction due to HIV-mimetic anti-platelet antibodies, and increased use of activated platelets. Activated platelets have the potential to contribute to the pathogenesis of HIV and SIV by interacting directly with inflammatory cells and endothelium and by releasing soluble immunomodulatory cytokines.

摘要

血小板减少症在HIV和SIV感染中很常见，并且常常与疾病进展相关。HIV和SIV相关的血小板减少症通过多种机制产生，包括血小板生成减少、由于模仿HIV的抗血小板抗体导致的血小板破坏增加，以及活化血小板的使用增加。活化血小板有可能通过直接与炎症细胞和内皮细胞相互作用以及释放可溶性免疫调节细胞因子来促进HIV和SIV的发病机制。