TNF 阻断剂治疗下的疫苗接种——效果较差，但仍有价值。
Vaccination under TNF blockade - less effective, but worthwhile.
出版信息
Arthritis Res Ther. 2012 May 14;14(3):117. doi: 10.1186/ar3808.
Abstract
Only after biological response modifiers have become available have we begun to understand some of the complex functions of TNF in the human immune system. TNF is clearly essential for fighting intracellular pathogens, but probably not essential for fighting tumors. TNF influence on the humoral immune response, in contrast, has been more complicated to decipher, since TNF blockade is associated with both autoantibody formation and (somewhat) reduced responses to vaccination. Novel data now show that TNF is good for the humoral immune response. Vaccinations still work, however, and should be strongly recommended.
摘要
只有在生物反应调节剂问世后，我们才开始了解 TNF 在人体免疫系统中的一些复杂功能。TNF 显然对于对抗细胞内病原体是必不可少的，但对于对抗肿瘤可能并非必不可少。相比之下，TNF 对体液免疫反应的影响更难解读，因为 TNF 阻断与自身抗体形成和（在某种程度上）对疫苗接种的反应降低有关。新数据表明，TNF 有利于体液免疫反应。然而，疫苗仍然有效，因此应该强烈推荐。
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