Diabetes, Obesity and Human Reproduction Research Group, University of Alcalá and Hospital Universitario Ramón y Cajal and Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM & Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Carretera de Colmenar km 9'1, E-28034 Madrid, Spain.
Trends Endocrinol Metab. 2012 Oct;23(10):509-15. doi: 10.1016/j.tem.2012.04.003. Epub 2012 May 10.
The polycystic ovary syndrome (PCOS) is associated with insulin resistance and abnormal glucose tolerance. Iron overload may lead also to insulin resistance and diabetes. Serum ferritin levels are increased in PCOS, especially when glucose tolerance is abnormal, suggesting mild iron overload. Factors contributing to potential iron overload in PCOS include the iron sparing effect of chronic menstrual dysfunction, insulin resistance, and a decrease in hepcidin leading to increased iron absorption. Enhancement of erythropoiesis by androgen excess is unlikely, because soluble transferrin receptor levels are not increased in PCOS. Future venues of research should address the long-term effects of PCOS treatment on iron overload and, conversely, the possible effects of iron lowering strategies on the glucose tolerance of patients with PCOS.
多囊卵巢综合征（PCOS）与胰岛素抵抗和异常葡萄糖耐量有关。铁过载也可能导致胰岛素抵抗和糖尿病。多囊卵巢综合征患者的血清铁蛋白水平升高，尤其是在葡萄糖耐量异常时，提示存在轻度铁过载。导致多囊卵巢综合征潜在铁过载的因素包括慢性月经功能障碍的铁节约效应、胰岛素抵抗以及铁调素减少导致铁吸收增加。雄激素过多增强红细胞生成的可能性不大，因为多囊卵巢综合征患者的可溶性转铁蛋白受体水平没有增加。未来的研究方向应该是探讨多囊卵巢综合征治疗对铁过载的长期影响，以及相反地，降低铁水平策略对多囊卵巢综合征患者葡萄糖耐量的可能影响。
