Servicio de Bioquímica Clínica, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain.
Clin Chim Acta. 2013 Jan 16;415:350-60. doi: 10.1016/j.cca.2012.04.027. Epub 2012 May 2.
The classification, distribution and functions of the different molecules of aquaporins (AQPs), including aquaporins, aquaglyceroporins and superaquaporins are reviewed together with their potential diagnostic and therapeutic uses. We analyzed the pathogenic importance of anti-AQP4 autoantibodies in neuromyelitis optica and related syndromes, as well as their diagnostic and predictive potential, prognosis, and monitoring of the disease. Finally, the analytical methods and current recommendations for testing anti-AQP4 autoantibodies in clinical practice are described.
本文综述了不同水通道蛋白（AQPs）分子的分类、分布和功能，包括水通道蛋白、水甘油通道蛋白和超水通道蛋白，并探讨了其在诊断和治疗中的潜在应用。我们分析了抗 AQP4 自身抗体在视神经脊髓炎和相关综合征中的致病重要性，以及它们的诊断和预测潜力、预后和疾病监测。最后，描述了分析方法和目前在临床实践中检测抗 AQP4 自身抗体的建议。
