2nd Division of Interventional Cardiology, Onassis Cardiac Surgery Center, Athens, Greece.
Clin Biochem. 2012 Nov;45(16-17):1513-5. doi: 10.1016/j.clinbiochem.2012.04.019. Epub 2012 May 2.
Osteopontin (OPN) is a multifunctional protein associated with vascular injury and has been linked to atherosclerosis and inflammation. We sought to investigate whether OPN changes in relation to coronary artery by-pass grafting (CABG) surgery.
We studied 50 consecutive patients (63 ± 10 years old, 6 women and 44 men) undergoing elective CABG. Plasma OPN levels were determined by an enzyme-linked immunosorbent assay at baseline and in 24 and 72 h, post-operatively. Cardiac enzymes - creatine kinase, the MB isoenzyme of creatine kinase, troponin-I- and C-reactive protein (CRP) were also determined at all three time points.
OPN levels 72 h post-op decreased significantly compared to pre-op and 24h post-op levels (p<0.001) whereas there was no difference between the pre-op and first post-op values (p=0.57). The relative change in OPN levels between pre-op and 72 h post-op correlated negatively with absolute troponin-I levels at 72 h post-op (-0.51, p=0.005). OPN levels 72 h post-op correlated significantly with CRP at baseline (r=0.73, p=0.002).
OPN plasma concentrations decreased after CABG surgery in the early post-operative period. The significance of this observation needs further investigation.
骨桥蛋白（OPN）是一种与血管损伤相关的多功能蛋白，与动脉粥样硬化和炎症有关。我们试图研究与冠状动脉旁路移植术（CABG）相关的 OPN 变化。
我们研究了 50 例连续患者（63±10 岁，6 名女性和 44 名男性）行择期 CABG。在基线和术后 24 和 72 小时，通过酶联免疫吸附试验测定血浆 OPN 水平。在所有三个时间点也测定了心脏酶-肌酸激酶、肌酸激酶同工酶 MB、肌钙蛋白 I 和 C 反应蛋白（CRP）。
与术前和术后 24 小时相比，术后 72 小时 OPN 水平显著下降（p<0.001），而术前和术后第 1 次之间无差异（p=0.57）。术前与术后 72 小时 OPN 水平的相对变化与术后 72 小时的绝对肌钙蛋白 I 水平呈负相关（-0.51，p=0.005）。术后 72 小时 OPN 水平与基线时 CRP 显著相关（r=0.73，p=0.002）。
CABG 手术后 OPN 血浆浓度在术后早期下降。这一观察结果的意义需要进一步研究。
