Institute of Plant Biology, National Taiwan University, Taipei, Taiwan.
Plant Signal Behav. 2012 Jun;7(6):633-5. doi: 10.4161/psb.19994. Epub 2012 May 14.
One of the most fundamental questions in the control of gene expression is how epigenetic patterns of DNA methylation and histone modifications are established. Our recent studies demonstrate that histone deacetylase HDA6 integrates DNA methylation and histone modifications in gene silencing by interacting with DNA methyltransferase MET1 and histone demethylase FLD, suggesting that regulatory crosstalk between histone modifications and DNA methylation could be mediated by the interaction of various epigenetic modification proteins.
在基因表达调控中，最基本的问题之一是如何建立 DNA 甲基化和组蛋白修饰的表观遗传模式。我们最近的研究表明，组蛋白去乙酰化酶 HDA6 通过与 DNA 甲基转移酶 MET1 和组蛋白去甲基化酶 FLD 相互作用，整合 DNA 甲基化和组蛋白修饰来实现基因沉默，这表明组蛋白修饰和 DNA 甲基化之间的调控串扰可能是由各种表观遗传修饰蛋白的相互作用介导的。
