Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China.
Mol Med Rep. 2012 Aug;6(2):271-4. doi: 10.3892/mmr.2012.911. Epub 2012 May 9.
Distant metastasis is a common cause of mortality in patients with salivary gland adenoid cystic carcinoma (SACC). However, presently, the development of distant metastasis is unable to be predicted in clinical practice. Recent studies have shown that overexpression of podoplanin is associated with metastasis and survival in patients with several cancer types. The purpose of the present study was to determine whether podoplanin is overexpressed in SACC and whether such overexpression is associated with distant metastasis and survival. Podoplanin expression was determined using immunohistochemistry (IHC) in tumors from 40 SACC patients. The expression status was analyzed in regards to patient clinicopathological parameters and survival rates. Overexpression of podoplanin was detected in 13 (32.5%) of the 40 tumors. Overexpression was significantly associated with disease-free survival (P=0.025) and distant metastasis (P=0.015), although it was not associated with recurrence and overall survival. In conclusion, podoplanin is overexpressed in a subset of SACCs and may be a biomarker predicting distant metastasis in patients with SACC.
远处转移是唾液腺腺样囊性癌（SACC）患者死亡的常见原因。然而，目前在临床实践中无法预测远处转移的发展。最近的研究表明，波形蛋白的过表达与几种癌症类型患者的转移和生存有关。本研究旨在确定波形蛋白是否在 SACC 中过表达，以及这种过表达是否与远处转移和生存有关。使用免疫组织化学（IHC）检测 40 名 SACC 患者肿瘤中的波形蛋白表达。分析了表达状态与患者临床病理参数和生存率的关系。在 40 个肿瘤中，有 13 个（32.5%）检测到波形蛋白过表达。波形蛋白过表达与无病生存率（P=0.025）和远处转移（P=0.015）显著相关，尽管与复发和总生存率无关。总之，波形蛋白在 SACC 的一个亚组中过表达，可能是预测 SACC 患者远处转移的生物标志物。
