Xia Zhi-Ming, Hu Ya-Er
Research Library of Cell Regulation of Cell Regulation, Shanghai Jiaotong University Medical School, Shanghai 200025, China.
Sheng Li Ke Xue Jin Zhan. 2012 Feb;43(1):5-10.
Loss of synapses correlates well with cognitive decline in Alzheimer's disease (AD). However, the molecular mechanisms underlying the synaptic dysfunction and loss are not well understood. Synaptic vesicle (SV) recycling is a key process for synaptic transmission. A body of evidences suggested that malfunction or loss of the machinery for SV recycling occurred in AD, which could result in disruption of neuronal circuitry. In this article, we summarized the recent progress in the research of synaptic proteins for SV recycling and the pathological changes of some proteins in AD.
突触丢失与阿尔茨海默病（AD）的认知衰退密切相关。然而，突触功能障碍和丢失背后的分子机制尚未完全明确。突触小泡（SV）循环是突触传递的关键过程。大量证据表明，AD中发生了SV循环机制的功能障碍或丧失，这可能导致神经回路的破坏。在本文中，我们总结了SV循环突触蛋白研究的最新进展以及AD中一些蛋白质的病理变化。
