Montay G, Gaillot J
Institut de Biopharmacie, Rhône-Poulenc Santé, Antony, France.
J Antimicrob Chemother. 1990 Oct;26 Suppl B:61-7. doi: 10.1093/jac/26.suppl_b.61.
In patients with alcoholic cirrhosis, the pharmacokinetics of the fluoroquinolones were variously altered. The kinetics of ciprofloxacin were slightly modified in patients with mild or moderate impairment. Ofloxacin kinetics were influenced by renal dysfunction encountered in patients with ascites. Pefloxacin kinetics were markedly modified with wide variations in elimination among patients. Ascitic penetration of ofloxacin and pefloxacin was excellent. Since no relationship between ofloxacin or pefloxacin kinetics and the usual liver function tests was found, recommended dosage regimens in cirrhotic patients have to be controlled by monitoring plasma drug levels during treatment.
在酒精性肝硬化患者中，氟喹诺酮类药物的药代动力学发生了不同程度的改变。轻度或中度肝功能损害患者的环丙沙星动力学略有改变。氧氟沙星的动力学受腹水患者出现的肾功能不全影响。培氟沙星的动力学有明显改变，患者间消除差异很大。氧氟沙星和培氟沙星的腹水穿透性良好。由于未发现氧氟沙星或培氟沙星动力学与常规肝功能检查之间存在关联，肝硬化患者的推荐给药方案在治疗期间必须通过监测血浆药物水平来控制。
