Kelentey B A, Kelentey B J, Fekete I, Kozma J
Debreceni Orvostudományi Egyetem, Stomatologiai Klinika, Gyógyszertani Intézet, Debrecen.
Fogorv Sz. 1995 Sep;88(9):293-7.
The excretion of three fluoroquinolones derivatives into the saliva were studied in animal experiments. Ofloxacin per os administered to rabbits was excreted into the saliva well, and maintained the therapeutic level long--about 7 hours. Pefloxacin and ciprofloxacin iv. administered to mice were similarly excreted into the saliva at therapeutic levels and retained the antibacterial level for about 4 hours.
在动物实验中研究了三种氟喹诺酮衍生物在唾液中的排泄情况。给兔子口服氧氟沙星后，其在唾液中排泄良好，并能长时间维持治疗水平——约7小时。给小鼠静脉注射培氟沙星和环丙沙星后，它们同样能以治疗水平排泄到唾液中，并保持抗菌水平约4小时。
