Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Diabetes Care. 2012 Aug;35(8):1701-7. doi: 10.2337/dc11-1690. Epub 2012 May 14.
To examine the relation of fatty acid-binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults.
We ascertained incident diabetes among 3,740 Cardiovascular Health Study participants (1992-2007) based on the use of hypoglycemic medications, fasting glucose ≥ 126 mg/dL, or nonfasting glucose ≥ 200 mg/dL. FABP4 and NEFA were measured on specimens collected between 1992 and 1993.
Mean age of the 3,740 subjects studied was 74.8 years. For each SD increase in log FABP4, hazard ratios (HRs) for diabetes were 1.35 (95% CI 1.10-1.65) for women and 1.45 (1.13-1.85) for men controlling for age, race, education, physical activity, cystatin C, alcohol intake, smoking, self-reported health status, and estrogen use for women (P for sex-FABP4 interaction 0.10). BMI modified the FABP4-diabetes relation (P = 0.009 overall; 0.02 for women and 0.135 for men), in that statistically significant higher risk of diabetes was mainly seen in men with BMI <25 kg/m(2) (HR per SD: 1.78 [95% CI 1.13-2.81]). There was a modest and nonsignificant association of NEFA with diabetes (P(trend) = 0.21). However, when restricted to the first 5 years of follow-up, multivariable-adjusted HRs for diabetes were 1.0 (ref.), 1.68 (95% CI 1.12-2.53), and 1.63 (1.07-2.50) across consecutive tertiles of NEFA (P(trend) = 0.03).
Plasma FABP4 was positively associated with incident diabetes in older adults, and such association was statistically significant in lean men only. A significant positive association between plasma NEFA and incident diabetes was observed during the first 5 years of follow-up.
研究脂肪酸结合蛋白（FABP）4 和非酯化脂肪酸（NEFA）与老年人糖尿病之间的关系。
我们根据使用降血糖药物、空腹血糖≥126mg/dL 或非空腹血糖≥200mg/dL，在 3740 名心血管健康研究参与者（1992-2007 年）中确定了新发生的糖尿病。FABP4 和 NEFA 是在 1992 年至 1993 年期间采集的标本上测量的。
3740 名研究对象的平均年龄为 74.8 岁。对于每个 SD 增加的 log FABP4，女性糖尿病的危险比（HR）为 1.35（95%CI 1.10-1.65），男性为 1.45（1.13-1.85），控制年龄、种族、教育程度、身体活动、胱抑素 C、酒精摄入、吸烟、自我报告的健康状况和女性雌激素使用（性别-FABP4 交互作用 P = 0.10）。BMI 改变了 FABP4 与糖尿病的关系（总体 P = 0.009；女性 P = 0.02，男性 P = 0.135），BMI <25kg/m2 的男性发生糖尿病的风险显著升高（每 SD 的 HR：1.78 [95%CI 1.13-2.81]）。NEFA 与糖尿病有适度但无统计学意义的关联（P（趋势）= 0.21）。然而，在随访的前 5 年内，连续三分之 NEFA 的多变量校正后糖尿病的 HR 为 1.0（参考）、1.68（95%CI 1.12-2.53）和 1.63（1.07-2.50）（趋势 P = 0.03）。
血浆 FABP4 与老年人的新发糖尿病呈正相关，且仅在偏瘦的男性中具有统计学意义。在随访的前 5 年内，血浆 NEFA 与新发糖尿病之间存在显著的正相关。
