School of Medicine, Tzu Chi University, Hualien, Taiwan.
Circ J. 2010 Feb;74(2):327-31. doi: 10.1253/circj.cj-09-0568. Epub 2009 Dec 14.
The serum level of fatty-acid-binding protein 4 (FABP4) increases in patients with metabolic syndrome (MetS), so the relationship between FABP4 and MetS among patients with coronary artery disease (CAD) was investigated in the present study.
Fasting blood samples were obtained from 98 CAD patients. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation; 50 CAD patients (51.0%) had MetS. The fasting level of FABP4 positively correlated with MetS (P=0.037) and serum levels of FABP4 correlated with a number of MetS criteria (P=0.035). Univariate linear regression analysis showed that body fat mass (R=0.234; P=0.020) and the levels of triglycerides (R=0.348; P<0.001), and low-density lipoprotein-cholesterol (R=0.217; P=0.032) positively correlated with the serum level of FABP4, whereas the level of high-density lipoprotein-cholesterol (R=-0.243; P=0.016) negatively correlated with it. Multivariate forward stepwise linear regression analysis of the significant variables showed that the level of triglycerides (beta=0.348, R(2)=0.121, P<0.001) was the independent predictor of fasting serum level of FABP4.
Among CAD patients in the present study, the fasting level of FABP4 positively correlated with MetS and serum levels of FABP4 correlated with a number of MetS criteria.
脂肪酸结合蛋白 4（FABP4）的血清水平在代谢综合征（MetS）患者中升高，因此本研究调查了冠心病（CAD）患者中 FABP4 与 MetS 的关系。
从 98 例 CAD 患者中采集空腹血样。使用国际糖尿病联合会的诊断标准定义 MetS 及其成分；50 例 CAD 患者（51.0%）患有 MetS。FABP4 的空腹水平与 MetS 呈正相关（P=0.037），并且 FABP4 的血清水平与多个 MetS 标准相关（P=0.035）。单变量线性回归分析显示，体脂肪量（R=0.234；P=0.020）和甘油三酯水平（R=0.348；P<0.001）以及低密度脂蛋白胆固醇（R=0.217；P=0.032）与 FABP4 的血清水平呈正相关，而高密度脂蛋白胆固醇水平（R=-0.243；P=0.016）与 FABP4 的血清水平呈负相关。对有意义变量的多元逐步线性回归分析显示，甘油三酯水平（β=0.348，R(2)=0.121，P<0.001）是 FABP4 空腹血清水平的独立预测因子。
在本研究的 CAD 患者中，FABP4 的空腹水平与 MetS 呈正相关，并且 FABP4 的血清水平与多个 MetS 标准相关。
