Center for Functional and Restorative Neurosurgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19106, USA.
Ann Surg. 2012 Aug;256(2):251-4. doi: 10.1097/SLA.0b013e3182565712.
The present meta-regression pools data from reports of long-term follow-up (>2 years) to assess durability of the efficacy associated with Roux-en-Y gastric bypass (RYGB) surgery.
Medline and PubMed searches for articles pertaining to long-term weight loss after RYGB surgery were performed.
Various studies have consistently shown short-term (<2 years) efficacy of RYGB surgery for morbid obesity, corroborated by meta-analytic techniques. Relatively few studies have assessed efficacy over longer periods of time. This is the first meta-analysis to analyze long-term effects of RYGB surgery on weight loss.
Twenty-two reports with a total of 4206 patient cases were included. Sixteen of the 22 studies had multiple follow-up times, ranging from 2 to 12.3 years (mean: 3.6 years). An inverse variance weighted model and meta-regression were used to generate the pooled percent mean excess weight loss (EWL) and the durability of EWL over time, respectively.
Meta-regression did not reveal any significant change in EWL over time. Pooled mean EWL was 66.5%, and there was no significant association between EWL and length of follow-up.
Pooling data from multiple studies meta-analytically revealed that weight loss after RYGB is maintained over the long-term. Further investigation would be necessary to ascertain similar durability in comorbidity reduction after RYGB surgery.
本荟萃回归分析汇总了长期随访（>2 年）报告的数据，以评估 Roux-en-Y 胃旁路（RYGB）手术相关疗效的持久性。
对有关 RYGB 手术后长期减重的文章进行了 Medline 和 PubMed 检索。
各种研究一致表明 RYGB 手术对病态肥胖的短期（<2 年）疗效，这得到了荟萃分析技术的证实。相对较少的研究评估了更长时间的疗效。这是首次对 RYGB 手术对体重减轻的长期效果进行分析的荟萃分析。
共纳入 22 项研究，总计 4206 例患者。22 项研究中有 16 项有多个随访时间，范围为 2 至 12.3 年（平均 3.6 年）。采用逆方差加权模型和荟萃回归分别生成汇总的平均超重减轻百分比（EWL）和 EWL 随时间的持久性。
荟萃回归未显示 EWL 随时间的任何显著变化。汇总的平均 EWL 为 66.5%，EWL 与随访时间之间无显著关联。
对多项研究的数据进行荟萃分析表明，RYGB 后的体重减轻可以长期维持。需要进一步研究以确定 RYGB 手术后减少并发症的类似持久性。
