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婴儿心脏手术后的交界性异位性心动过速:发病率及预后

Junctional ectopic tachycardia after infant heart surgery: incidence and outcomes.

作者信息

Zampi Jeffrey D, Hirsch Jennifer C, Gurney James G, Donohue Janet E, Yu Sunkyung, LaPage Martin J, Hanauer David A, Charpie John R

机构信息

Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109-4204, USA.

出版信息

Pediatr Cardiol. 2012 Dec;33(8):1362-9. doi: 10.1007/s00246-012-0348-y. Epub 2012 May 15.

Abstract

Junctional ectopic tachycardia (JET) is an arrhythmia observed almost exclusively after open heart surgery in children. Current literature on JET has not focused on patients at the highest risk of both developing and being negatively impacted by JET. The purpose of this study was to determine the overall incidence of JET in an infant patient cohort undergoing open cardiac surgery, to identify patient- and procedure-related factors associated with developing JET, and to assess the clinical impact of JET on patient outcomes. We performed a nested case-control study from the complete cohort of patients at our institution younger than 1 year of age who underwent open heart surgery between 2005 and 2010. JET patients were compared with an age matched control group undergoing open heart surgery without JET regarding potential risk factors and outcomes. The overall incidence of JET in infants after open cardiac surgery was 14.3 %. From multivariate analyses, complete repair of tetralogy of Fallot [adjusted odds ratio (AOR) 2.0, 95 % CI 1.12-3.57] and longer aortic cross clamp times (AOR 1.02, 95 % CI 1.01-1.03) increased the risk of developing JET. Patients with JET had longer length of intubation, intensive care unit stays, and total length of hospitalization, and were more likely to require extracorporeal membrane oxygenation support (13 vs. 4.3 %). JET is a common postoperative arrhythmia in infants after open heart operations. Both anatomic substrate and surgical procedure contribute to the overall risk of developing JET. Developing JET is associated with worse clinical outcomes.

摘要

交界性异位性心动过速(JET)几乎仅在儿童心脏直视手术后观察到。目前关于JET的文献尚未关注那些发生JET且受其负面影响风险最高的患者。本研究的目的是确定接受心脏直视手术的婴儿患者队列中JET的总体发生率,识别与发生JET相关的患者和手术相关因素,并评估JET对患者预后的临床影响。我们对2005年至2010年间在我院接受心脏直视手术的年龄小于1岁的全部患者队列进行了一项巢式病例对照研究。将发生JET的患者与年龄匹配的未发生JET的心脏直视手术对照组在潜在危险因素和预后方面进行比较。心脏直视手术后婴儿中JET的总体发生率为14.3%。多因素分析显示,法洛四联症的完全修复(调整优势比[AOR] 2.0,95%可信区间[CI] 1.12 - 3.57)和较长的主动脉阻断时间(AOR 1.02,95% CI 1.01 - 1.03)增加了发生JET的风险。发生JET的患者插管时间、重症监护病房住院时间和总住院时间更长,且更有可能需要体外膜肺氧合支持(13%对4.3%)。JET是婴儿心脏直视手术后常见的术后心律失常。解剖学基础和手术操作均会增加发生JET的总体风险。发生JET与更差的临床预后相关。

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