Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey.
Anat Rec (Hoboken). 2012 Jul;295(7):1202-11. doi: 10.1002/ar.22493. Epub 2012 May 14.
The aim of this study was to investigate the shape differences in the corpus callosum (CC) and cerebellum of female relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS) patients compared with healthy controls. This study was conducted using the magnetic resonance imaging scans of 15 control subjects, 26 RRMS, and 14 SPMS patients. The data obtained from the landmark coordinates were analyzed with statistical shape analysis. The landmarks that were chosen to determine the shape differences of the CC and cerebellum have been identified and used in previous studies. In addition to these landmarks, constructed landmarks were determined and used to assess regional shape differences better. The shapes of the CC and cerebellum showed statistically significant differences from the controls when compared with both the RRMS and SPMS patients. It was found that the deformation observed from controls to SPMS was greater than the deformation from controls to RRMS, both for the CC and cerebellum. In conclusion, this study revealed CC and cerebellar shape change in RRMS and SPMS, and showed that deformations both in CC and cerebellum advances with the disease progression.
本研究旨在探究女性复发缓解型多发性硬化症（RRMS）和继发进展型多发性硬化症（SPMS）患者与健康对照组之间胼胝体（CC）和小脑的形状差异。该研究使用了 15 名对照受试者、26 名 RRMS 和 14 名 SPMS 患者的磁共振成像扫描。使用统计形状分析对从地标坐标获得的数据进行了分析。用于确定 CC 和小脑形状差异的地标已在前研究中确定并使用。除了这些地标外，还确定了构建地标，以更好地评估区域形状差异。与 RRMS 和 SPMS 患者相比，CC 和小脑的形状与对照组相比显示出统计学上的显著差异。结果发现，与 RRMS 相比，从对照组到 SPMS 的变形更大，CC 和小脑均如此。总之，本研究揭示了 RRMS 和 SPMS 中 CC 和小脑的形状变化，并表明 CC 和小脑的变形随着疾病的进展而进展。
