血液系统恶性肿瘤病史患者的头颈部继发恶性肿瘤。
Secondary head and neck cancer in patients with history of hematological malignancy.
机构信息
Division of Otorhinolaryngology-Head & Neck Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Regions, People's Republic of China.
出版信息
Head Neck. 2013 May;35(5):729-32. doi: 10.1002/hed.23026. Epub 2012 May 15.
BACKGROUND
Head and neck cancer is a common second cancer in patients with a history of hematological malignancies. The purpose of this study was present the clinical characteristics and treatment outcomes of this group of patients.
METHODS
A retrospective analysis was conducted of all patients who had a history of hematological malignancy and developed head and neck cancer in a 10-year period.
RESULTS
The cohort had 10 patients; median age was 45.8 years. Most patients were nonsmokers and nondrinkers. Seven patients had chronic graft-versus-host disease. The median interval between the completion of treatment of hematological malignancy and the development of head and neck cancers was 8.79 years (range, 2.33-26.83 years). Six patients were alive and disease-free, 3 developed local recurrence, and 3 had metachronous head and neck cancers.
CONCLUSION
The risk factors and etiology of head and neck cancers in patients with hematological malignancy may be different from the ordinary population.
背景
头颈部癌症是血液系统恶性肿瘤病史患者中常见的第二原发癌。本研究旨在介绍这组患者的临床特征和治疗结果。
方法
对 10 年间患有血液系统恶性肿瘤且发生头颈部癌症的所有患者进行回顾性分析。
结果
该队列共有 10 例患者；中位年龄为 45.8 岁。大多数患者不吸烟、不饮酒。7 例患者患有慢性移植物抗宿主病。血液系统恶性肿瘤治疗完成与头颈部癌症发生之间的中位间隔时间为 8.79 年（范围为 2.33-26.83 年）。6 例患者存活且无疾病，3 例出现局部复发，3 例发生了异时性头颈部癌症。
结论
血液系统恶性肿瘤患者发生头颈部癌症的危险因素和病因可能与普通人群不同。
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