新途径通往旧领域：PIK3R1 和 PIK3R2 与 PIK3CA 和 PTEN 一起成为子宫内膜癌基因。
New routes to old places: PIK3R1 and PIK3R2 join PIK3CA and PTEN as endometrial cancer genes.
机构信息
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
出版信息
Cancer Discov. 2011 Jul;1(2):106-7. doi: 10.1158/2159-8290.CD-11-0116.
PMID:22586352
Abstract
Cheung and colleagues identify PIK3R1 and PIK3R2, the genes encoding the α and β isoforms of the phosphatidylinositol 3-kinase (PI3K) p85 regulatory subunit, as additional mutation targets in endometrial cancer, and describe a novel mechanism leading to PTEN loss.
摘要
张和同事们确定了 PIK3R1 和 PIK3R2，即编码磷脂酰肌醇 3-激酶 (PI3K) p85 调节亚基的 α 和 β 同工型的基因，作为子宫内膜癌的其他突变靶点，并描述了导致 PTEN 缺失的新机制。
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