Department of Mathematics, Faculty of Science, Banaras Hindu University, Varanasi 221005, India.
J Theor Biol. 2012 May 21;301:49-56. doi: 10.1016/j.jtbi.2012.02.006.
A non-linear SIRS mathematical model to explore the dynamics of water borne diseases like cholera is proposed and analyzed by incorporating delay in using disinfectants to control the disease. It is assumed that the only way for the spread of infection is ingestion of contaminated water by susceptibles. As the pathogens discharged by infectives reach to the aquatic environment, it is assumed that the growth rate of pathogens is proportional to the number of infectives. Further, it is assumed that disinfectants are introduced to kill pathogens with a rate proportional to the density of pathogens in the aquatic environment. The model is analyzed by using stability theory of delay differential equations. It is found that the model exhibits two equilibria, the disease free equilibrium and the endemic equilibrium. The analysis shows that under certain conditions, the cholera disease may be controlled by using disinfectants but a longer delay in their use may destabilize the system. Numerical simulation is also carried out to confirm the analytical results.
提出并分析了一个带有时滞的非线性 SIRS 数学模型,用于探索像霍乱这样的水传播疾病的动力学。假设感染的唯一途径是易感人群摄入受污染的水。由于感染者排出的病原体到达水生环境,假设病原体的增长率与感染者的数量成正比。此外,假设消毒剂的引入是为了杀死病原体,其速率与水生环境中病原体的密度成正比。该模型是通过使用时滞微分方程稳定性理论来分析的。结果表明,该模型表现出两个平衡点,即无病平衡点和地方病平衡点。分析表明,在某些条件下,消毒剂的使用可以控制霍乱疾病,但如果延迟使用消毒剂,可能会使系统失稳。还进行了数值模拟来验证分析结果。