Lang Qing-bo, Zhai Dong-xia, Huang Feng, Chen Jian-guo, Zhang Yong-hui, Liu Qun, Zhai Xiao-feng, Li Bai, Ling Chang-quan
Department of Traditional Chinese Medicine, Second Military Medical University, Shanghai, China.
Zhong Xi Yi Jie He Xue Bao. 2012 May;10(5):525-31. doi: 10.3736/jcim20120507.
To study the traditional Chinese medicine (TCM) syndrome distribution in patients with hepatitis B virus (HBV) infection in Qidong region of Jiangsu Province, China.
A cross-sectional survey was performed. Subjects from Qidong of Jiangsu Province of China were screened among the locally enrolled residents by detecting hepatitis B surface antigen (HBsAg) from May 2007 to May 2011 and were assigned to HBsAg-negative cohort or HBsAg-positive cohort. Then, the subjects were diagnosed according to alanine aminotransferase, alpha-fetoprotein and B ultrasound. The syndrome of the subjects was determined using a TCM questionnaire consisting of signs and symptoms.
A total of 5 908 subjects were enrolled in this survey, among whom, 4 718 were diagnosed with HbsAg infection (positive result of HbsAg detection) and 1 147 were negative. 143 subjects were excluded for not receiving the blood examination. The final diagnoses of the subjects were non-HBV infection (n=1128), HBV carrier (n=4019), chronic hepatitis B (n=225), posthepatitic cirrhosis (n=263) or liver cancer (n=111). The TCM syndrome differentiation results showed that there were differences in syndrome distribution between HBV-infected and non-HBV-infected patients. The main syndromes of the HBV-infected patients were qi deficiency, qi stagnation, blood stasis and dampness heat, related to the Zang of liver and spleen. The distribution principles of TCM syndrome among patients of HBV carrier, chronic hepatitis B and cirrhosis were similar. Moreover, with the progression of the patients' condition, the scores of syndromes increased, and the number of accompanying syndromes increased as well. The main syndromes of patients with liver cancer were blood stasis and excess heat, which was slightly different from that of the other HBV-infected patients.
The TCM syndrome distribution in patients of HBV infection in Qidong region of Jiangsu Province shows regularity. The disorder is mainly due to qi stagnation and blood stasis and is also related to deficiency of healthy qi, especially deficiency of spleen qi.
研究中国江苏省启东地区乙型肝炎病毒（HBV）感染患者的中医证候分布情况。
进行横断面调查。于2007年5月至2011年5月期间，在中国江苏省启东地区当地登记居民中通过检测乙型肝炎表面抗原（HBsAg）进行筛查，将受试者分为HBsAg阴性队列或HBsAg阳性队列。然后，根据丙氨酸氨基转移酶、甲胎蛋白和B超对受试者进行诊断。使用由症状和体征组成的中医问卷确定受试者的证候。
本研究共纳入5908名受试者，其中4718名被诊断为HBsAg感染（HBsAg检测结果为阳性），1147名呈阴性。143名受试者因未接受血液检查而被排除。受试者的最终诊断为非HBV感染（n = 1128）、HBV携带者（n = 4019）、慢性乙型肝炎（n = 225）、肝炎后肝硬化（n = 263）或肝癌（n = 111）。中医证候辨证结果显示，HBV感染患者与非HBV感染患者的证候分布存在差异。HBV感染患者的主要证候为气虚、气滞、血瘀和湿热，与肝脾脏腑相关。HBV携带者、慢性乙型肝炎和肝硬化患者的中医证候分布规律相似。此外，随着患者病情进展，证候得分增加，兼夹证候数量也增加。肝癌患者的主要证候为血瘀和实热，与其他HBV感染患者略有不同。
江苏省启东地区HBV感染患者的中医证候分布具有规律性。病变主要因气滞血瘀，也与正气亏虚，尤其是脾气虚有关。
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