细胞、神经营养因子、细胞外基质和细胞表面分子在周围神经再生中的作用。
The role of cells, neurotrophins, extracellular matrix and cell surface molecules in peripheral nerve regeneration.
作者信息
Naidu Murali
机构信息
Department of Anatomy, Faculty of Medicine, 50603 University Malaya, Malaysia.
出版信息
Malays J Med Sci. 2009 Apr;16(2):10-4.
Abstract
Wallerian degeneration is a complicated process whereby axons and myelin sheaths undergo degeneration, and eventually are phagocytosed by macrophages and Schwann cells following nerve damage. Schwann cells proliferate and the endoneural tubes persist. In addition, neurotrophins, neural cell adhesion molecules, cytokines and other soluble factors are upregulated to facilitate regeneration. The important role of cellular components, neurotrophins, and extracellular matrix components, including cell surface molecules involved in this regenerative process, is highlighted and discussed in this review.
摘要
沃勒变性是一个复杂的过程，在此过程中，轴突和髓鞘会发生变性，最终在神经损伤后被巨噬细胞和施万细胞吞噬。施万细胞增殖，神经内膜管持续存在。此外，神经营养因子、神经细胞黏附分子、细胞因子和其他可溶性因子会上调以促进再生。本文综述重点介绍并讨论了细胞成分、神经营养因子以及细胞外基质成分（包括参与这一再生过程的细胞表面分子）的重要作用。
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