Jessen K R, Mirsky R
Department of Anatomy and Developmental Biology, University College London, UK.
J Anat. 1997 Nov;191 ( Pt 4)(Pt 4):501-5. doi: 10.1046/j.1469-7580.1997.19140501.x.
The cellular events leading to the generation of Schwann cells from the neural crest have recently been clarified and it is now possible to outline a relatively simple model of the Schwann cell lineage in the rat and mouse. Neural crest cells have to undergo 3 main developmental transitions to become mature Schwann cells. These are the formation of Schwann cell precursors from crest cells, the formation of immature Schwann cells from precursors and, lastly, the postnatal and reversible generation of non-myelin- and myelin-forming Schwann cells. Axonal signals involving neuregulins are important regulators of these events, in particular of the survival, proliferation and differentiation of Schwann cell precursors.
最近，导致神经嵴产生施万细胞的细胞事件已得到阐明，现在有可能勾勒出大鼠和小鼠施万细胞谱系的一个相对简单的模型。神经嵴细胞必须经历3个主要的发育转变才能成为成熟的施万细胞。这些转变包括从嵴细胞形成施万细胞前体，从前体形成未成熟施万细胞，以及最后在出生后可逆地产生非髓鞘形成和髓鞘形成的施万细胞。涉及神经调节蛋白的轴突信号是这些事件的重要调节因子，特别是对施万细胞前体的存活、增殖和分化而言。
