肠道寄生虫感染的结直肠癌患者血清中过氧化氢水平降低及铁还原/抗氧化能力下降
Attenuation of hydrogen peroxide and ferric reducing/antioxidant power serum levels in colorectal cancer patients with intestinal parasitic infection.
作者信息
Chandramathi Samudi, Suresh Kumar Govind, Anita Zarina Bustam, Kuppusamy Umah Rani
机构信息
Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
出版信息
Malays J Med Sci. 2009 Apr;16(2):15-20.
BACKGROUND
This study assessed several common oxidative indices in subjects infected with intestinal parasites, as well as in colorectal cancer (CRC) patients both with and without intestinal parasites.
METHOD
Serum levels of malondialdehyde (MDA), ferric reducing/antioxidant power (FRAP), and hydrogen peroxide (H(2)O(2)) were measured, as were plasma levels of advanced oxidation protein products (AOPP), all according to established methods. The presence of intestinal parasites was confirmed by stool examination.
RESULTS
All intestinal parasiteinfected subjects and CRC patients showed the presence of oxidative stress. Thirtysix percent of the CRC patients had intestinal parasitic infections. The levels of H(2)O(2) and FRAP in parasite-infected subjects were significantly higher than in CRC patients, but these levels were significantly lower in the CRC patients with parasitic infections.
CONCLUSION
Parasitic infection and CRC may contribute to oxidative stress independently, but when present together, the oxidative stress burden imposed by parasites may be attenuated.
背景
本研究评估了肠道寄生虫感染患者以及伴有或不伴有肠道寄生虫的结直肠癌（CRC）患者的几种常见氧化指标。
方法
按照既定方法测量血清丙二醛（MDA）、铁还原/抗氧化能力（FRAP）和过氧化氢（H₂O₂）水平，以及血浆晚期氧化蛋白产物（AOPP）水平。通过粪便检查确认肠道寄生虫的存在。
结果
所有肠道寄生虫感染患者和CRC患者均存在氧化应激。36%的CRC患者有肠道寄生虫感染。寄生虫感染患者的H₂O₂和FRAP水平显著高于CRC患者，但在伴有寄生虫感染的CRC患者中这些水平显著较低。
结论
寄生虫感染和CRC可能独立导致氧化应激，但当两者同时存在时，寄生虫施加的氧化应激负担可能会减轻。
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