Kamsiah J, Nafeeza M
Department of Pharmacology.
Malays J Med Sci. 1999 Jul;6(2):5-11.
The effect of nicardipine on fasting plasma lipid profiles was studied in rabbits given a 2% cholesterol diet. Twenty four New Zealand White rabbits (2.2 - 2.8 kg) were divided into 3 groups. Group 1 (control) was fed a normal diet, group II (HC) was fed a 2% cholesterol diet and group III (HC+NICA) was fed a 2% cholesterol diet with nicardipine treatment (0.5mg kg(-1) body weight twice daily intramuscularly for 10 weeks). The following parameters which included fasting plasma total cholesterol, triglycerides, HDL cholesterol and apolipoprotein A and B were measured before and after 10 weeks of study. In the present study we observed that a 2% cholesterol diet caused a significant increase in plasma total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides. However, the increase in total cholesterol and LDL cholesterol were not prevented by treatment with nicardipine. Nicardipine appeared to cause further increase in HDL cholesterol and prevented further rise in plasma triglycerides after 10 weeks of treatment.
在给予2%胆固醇饮食的兔子中研究了尼卡地平对空腹血脂谱的影响。将24只新西兰白兔（体重2.2 - 2.8千克）分为3组。第1组（对照组）给予正常饮食，第II组（高胆固醇组，HC）给予2%胆固醇饮食，第III组（高胆固醇+尼卡地平组，HC+NICA）给予2%胆固醇饮食并进行尼卡地平治疗（每日两次肌肉注射0.5毫克/千克体重，持续10周）。在研究的10周前后测量以下参数，包括空腹血浆总胆固醇、甘油三酯、高密度脂蛋白胆固醇以及载脂蛋白A和B。在本研究中，我们观察到2%胆固醇饮食导致血浆总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯显著升高。然而，尼卡地平治疗未能阻止总胆固醇和低密度脂蛋白胆固醇的升高。尼卡地平似乎导致高密度脂蛋白胆固醇进一步升高，并在治疗10周后阻止了血浆甘油三酯的进一步升高。
