State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China.
J Transl Med. 2012 May 16;10:96. doi: 10.1186/1479-5876-10-96.
Heat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated.
Immunohistochemistry (IHC) was employed to examine the expression patterns of Hsp70, human leukocyte antigen -A (HLA-A) in NPC tissue samples.
The expression of Hsp70 exhibited different spatial patterns among nuclear, membrane and cytoplasm in 507 NPC tumor tissues. Kaplan-Meier survival analysis demonstrated that different Hsp70 expression patterns are correlated with different patient outcomes. High membranal and cytoplasmic levels of Hsp70 predicted good survival of patients. In contrast, high nuclear abundance of Hsp70 correlated with poor survival. Moreover, the membranal and cytoplasmic levels of Hsp70 were positively correlated with levels of the MHC I molecule HLA-A.
Different Hsp70 expression patterns had distinct predictive values. The different spatial abundance of Hsp70 may imply its important role in NPC development and provide insight for the development of novel therapeutic strategies involving immunotherapy for NPC.
热休克蛋白 70 是一种应激蛋白，其与肿瘤进展有关。然而，其在鼻咽癌（NPC）进展中的作用尚未得到明确研究。
采用免疫组织化学（IHC）检测 NPC 组织样本中 Hsp70、人类白细胞抗原-A（HLA-A）的表达模式。
在 507 例 NPC 肿瘤组织中，Hsp70 的表达呈现出核、膜和细胞质的不同空间模式。Kaplan-Meier 生存分析表明，不同的 Hsp70 表达模式与不同的患者结局相关。Hsp70 的高膜和细胞质水平预示着患者的良好生存。相反，Hsp70 的高核丰度与不良预后相关。此外，Hsp70 的膜和细胞质水平与 MHC I 分子 HLA-A 的水平呈正相关。
不同的 Hsp70 表达模式具有不同的预测价值。Hsp70 的不同空间丰度可能暗示其在 NPC 发展中的重要作用，并为涉及 NPC 免疫治疗的新型治疗策略的发展提供了见解。
Zotero 插件
