Thubashini M, Malathi N, Kannan L
Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College, Porur, Chennai, India.
Indian J Dent Res. 2011 Mar-Apr;22(2):256-9. doi: 10.4103/0970-9290.84299.
Heat shock proteins are a highly conserved group of protective cellular proteins whose synthesis is increased in response to a variety of environmental or pathophysiological stresses. Heat shock proteins are useful biomarkers for carcinogenesis in tissues and signal the degree of differentiation and the aggressiveness of cancers. Regulation of heat shock protein 70 (HSP70) expression in oral submucous fibrosis is not known much, and the aim of this study was to evaluate HSP70 expression in oral submucous fibrosis and oral squamous cell carcinoma by immunohistochemical method and to understand the role of HSP70 in tumorigenesis.
Immunohistochemical method was used to detect HSP70 expression in normal oral mucosa, oral submucous fibrosis (n=30) and oral squamous cell carcinoma (n=20). HSP70 immunoreactivity was correlated with histological and clinicopathological features.
A significant increase in expression of HSP70 was observed (P<0.000) as the tissue progressed from oral submucous fibrosis towards oral squamous cell carcinoma.
HSP70 is synthesized upon stress situations arising in cells of all living organisms. Expression of HSP70 indicates that stress plays an important role as a predisposing factor in oral submucous fibrosis and its subsequent progression to oral squamous cell carcinoma.
热休克蛋白是一类高度保守的细胞保护性蛋白，其合成会因各种环境或病理生理应激而增加。热休克蛋白是组织癌变的有用生物标志物，可表明癌症的分化程度和侵袭性。关于口腔黏膜下纤维化中热休克蛋白70（HSP70）表达的调控知之甚少，本研究的目的是通过免疫组织化学方法评估HSP70在口腔黏膜下纤维化和口腔鳞状细胞癌中的表达，并了解HSP70在肿瘤发生中的作用。
采用免疫组织化学方法检测正常口腔黏膜、口腔黏膜下纤维化（n = 30）和口腔鳞状细胞癌（n = 20）中HSP70的表达。HSP70免疫反应性与组织学和临床病理特征相关。
随着组织从口腔黏膜下纤维化发展为口腔鳞状细胞癌，观察到HSP70表达显著增加（P < 0.000）。
HSP70是在所有生物体细胞出现应激情况时合成的。HSP70的表达表明应激作为一个易感因素在口腔黏膜下纤维化及其随后发展为口腔鳞状细胞癌中起重要作用。
