大鼠原位肝移植的肝动脉重建。
Hepatic arterial reconstruction for orthotopic liver transplantation in the rat.
机构信息
Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida 32224, USA.
出版信息
J Surg Res. 2012 Dec;178(2):907-14. doi: 10.1016/j.jss.2012.04.039. Epub 2012 May 9.
BACKGROUND
Orthotopic liver transplantation (OLT) models in rats have been investigated in many studies. The reconstruction of hepatic artery is required for reliable OLT and also requires advanced skills.
METHODS
The hepatic artery reconstructions by a hand-suture technique and a new method using a micro T-tube were investigated in rats with a whole-liver syngeneic graft. Operative time and postoperative patency were compared between the hand-suture and micro T-tube techniques.
RESULTS
Our technique using the micro T-tube shortened the operative time of recipient surgery compared with the hand-suture technique and prolonged the operative time for the donor. The patency ratio was maintained at 24h after OLT with hand suturing but was significantly reduced with the micro T-tube, which had a patency ratio of 0.83 only up to 6h after OLT.
CONCLUSION
The micro T-tube technique may have potential usefulness in the rat OLT model but requires further modification.
背景
在许多研究中，已经对大鼠原位肝移植（OLT）模型进行了研究。可靠的 OLT 需要重建肝动脉，这也需要先进的技术。
方法
在大鼠全肝同种异体移植中，研究了一种使用手缝线技术和一种新的使用微 T 管的肝动脉重建方法。比较了手缝线技术和微 T 管技术的手术时间和术后通畅率。
结果
与手缝线技术相比，我们使用微 T 管的技术缩短了受体手术的手术时间，同时延长了供体的手术时间。肝动脉吻合后 24 小时的通畅率在手缝线组中维持，但在微 T 管组中显著降低，微 T 管组在肝动脉吻合后 6 小时的通畅率仅为 0.83。
结论
微 T 管技术在大鼠 OLT 模型中可能具有潜在的用途，但需要进一步改进。
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