Zahedi Hamid, Maleki Anahid, Rostami Gholamreza
Department of Anesthesiology, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
Acta Med Iran. 2012;50(4):239-43.
To assess the effectiveness of ondansetron pretreatment in alleviating propofol injection pain, 135 patients were randomly assigned to one of following three groups. Group 1 who received up to 2 mL pretreatment 50 mg tramadol in the saline, group 2 cases who received up to 2 mL pretreatment 4 mg ondansetron in saline, and group 3 who received up to 2 mL solution saline. A 20 gauge cannula was placed into the largest vein on the dorsum of the hand. Tourniquet was closed to the arm above the cannula and inflates to 70 mmHg, and then drug was injected. After 20 seconds, the tourniquet deflated, and propofol 2mg/kg injected over 10 seconds and pain assessment was made.
Tramadol and ondansetron significantly reduced the incidence and severity of propofol injection pain more than placebo (P=0.001). The efficacy of ondansetron in alleviating the pain on injection of propofol was no different from tramadol (P=0.330). Ondansetron pretreatment may be used to reduce the incidence of pain on injection of propofol, an advantage added to the useful prevention of postoperative nausea and vomiting.
为评估昂丹司琼预处理在减轻丙泊酚注射痛方面的有效性，135例患者被随机分为以下三组之一。第1组患者在盐水中接受最多2 mL的50 mg曲马多预处理，第2组患者在盐水中接受最多2 mL的4 mg昂丹司琼预处理，第3组患者接受最多2 mL的生理盐水溶液。将一根20号套管针插入手背最大的静脉。在套管针上方的手臂上扎上止血带并充气至70 mmHg，然后注射药物。20秒后，松开止血带，并在10秒内注射2mg/kg丙泊酚，同时进行疼痛评估。
曲马多和昂丹司琼比安慰剂更显著地降低了丙泊酚注射痛的发生率和严重程度（P = 0.001）。昂丹司琼减轻丙泊酚注射痛的效果与曲马多无差异（P = 0.330）。昂丹司琼预处理可用于降低丙泊酚注射痛的发生率，这是在有效预防术后恶心和呕吐之外的一个优势。
